Grapevine transcriptome atlas maps RNA diversity in developing clusters under gibberellin
An open RNA-seq dataset from gibberellin-treated and control Sistan Yaghooti grape clusters catalogs alternative splicing events, long non-coding RNAs and ...
Tag: alternative splicing
How Multilayered RNA Splicing Networks Drive Pancreatic Cancer Plasticity and Resistance
Researchers synthesize how coordinated epigenetic, transcriptional, and epitranscriptomic regulatory layers reshape alternative RNA splicing to drive pancreatic ductal adenocarcinoma progression ...
Blocking One Prolactin Receptor Isoform Selectively Disarms Lupus Immune Cells
Researchers report that a splice-modulating oligomer that reduces the long prolactin receptor isoform lowered pathogenic immune signatures in lupus patients' ...
TDP-43 Overexpression in Human Cells Reproduces Key ALS Pathology and Gene Changes
Scientists built an inducible human cell line that overproduces TDP-43, triggering toxicity, mislocalization, and gene expression changes that overlap with ...
Fruit Fly Eggshell Gene Reveals Purifying Selection with Episodes of Positive Evolution
A new study of the defective chorion 1 gene in two major pest fruit flies finds pervasive purifying selection punctuated ...
RNA-Binding Protein VCX3A Drives Spermatogonial Cell Proliferation and Motility Through Splicing Control
A new Cell & Bioscience study shows that the RNA-binding protein VCX3A cooperates with the splicing regulator KHDRBS1 to promote ...
RNA-Binding Protein hnRNPC Drives Cerebellar Growth by Guarding Mtf2 Splicing
A new mouse study shows that the RNA-binding protein hnRNPC supports cerebellar development by suppressing a cryptic exon in Mtf2 ...
Nuclear CK1α joins the WNT transcription machine to drive tumor-initiating cells
Nuclear L-insert-containing CK1α isoforms act as positive components of the β-catenin/TCF complex, while pharmacological CK1α activation with SSTC3 depletes WNT-driven ...
Cutting a Neck Nerve Rewires Gene Networks to Ease Rat Lung Hypertension
In a rat model of pulmonary arterial hypertension, surgically cutting the cervical sympathetic trunk lowered lung pressures and reshaped transcription ...
Adolescent Oxycodone Exposure Boosts Adult Opioid Self-Administration in Female Mice
A mouse study finds adolescent oxycodone exposure increases adult remifentanil self-administration in females but not males, with sex-specific gene expression ...
Exon-Skipping Splicing Changes Distinguish Alzheimer’s Disease from Progressive Supranuclear Palsy
A genomic study of temporal cortex tissue identifies hundreds of exon-skipping events that separate Alzheimer's disease from progressive supranuclear palsy, ...
Study confirms two novel alternatively spliced human RAB8B transcripts
A molecular biology study experimentally confirmed two novel human RAB8B transcripts and used computational models to predict differences in their ...
Gene architecture predicts isoform diversity across four genomes
Longer introns, shorter exons and more complex gene organization were consistently associated with higher transcript-isoform diversity in humans, mice, flies ...
Transcriptomic study links isoform remodeling to survival differences in clear cell renal cell carcinoma
A transcriptomic analysis of 127 ccRCC tumors found 1,170 differentially used transcripts, two expression subgroups with different angiogenic profiles and ...
Mechanical overload elicits weaker transcript isoform switching in aged mouse muscle
Mouse muscle subjected to mechanical overload showed extensive transcript isoform switching in adulthood, but the early response was attenuated in ...
Hidden RNA splice variant drives colorectal cancer spread, study finds
A tumor-specific splice variant of CALD1, driven by the splicing factor hnRNPA1 and acting through the motor protein MYH9, promotes ...
Splice Variants CLDN18.2 and FGFR2b Emerge as Prime Cancer Drug Targets
A new review maps how two splice-variant proteins, CLDN18.2 and FGFR2b, became leading cancer drug targets, and why next-generation antibodies, ...
A Hidden RNA Splice Variant May Predict Relapse After CD19 CAR-T Therapy
Danish researchers report that low-level skipping of CD19 exon 2, detectable in pre-treatment RNA-sequencing data, correlates with relapse after anti-CD19 ...
Hidden DNA Repeats in the Brain May Shape Splicing and Disease Risk
A large-scale analysis of 336 human prefrontal cortex samples identifies more than 51,000 short tandem repeats linked to alternative splicing ...
How microalgae and cyanobacteria rewrite their RNA to survive stress
A new review maps how alternative splicing rewires stress responses in microalgae while cyanobacteria rely on self-splicing introns and inteins, ...
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