A Single Botched Splice May Explain a Deadly Yellow-Leaf Soybean Mutant
Fine mapping of a soybean yellow-leaf lethal mutant has narrowed the cause to a 165-kilobase region on chromosome 10, where ...
Tag: alternative splicing
RNA-Binding Protein HuR Emerges as a Master Switch in Tau Splicing and Alzheimer’s Genes
A new study identifies the RNA-binding protein HuR as a repressor of tau exon 10 splicing and a regulator of ...
Tiny genetic switches: how microexons quietly rewire where proteins live in our cells
A new study shows that alternative splicing, especially through microexons shorter than five amino acids, fine-tunes protein interaction interfaces to ...
Hidden poison exons in the human brain reveal a new route into neurological disease
A genome-wide study identifies 9,814 poison exons in the human genome and shows that hundreds are brain-specific, linking their mis-splicing ...
How a Heat-Loving Plant Rewires Its RNA to Survive Scorching Temperatures
New research on the heat-tolerant shrub Rhododendron hainanense shows that escalating temperatures trigger a surge in alternative splicing that diversifies ...
One Gene, Two Proteins: Why CFH Cancer Biomarker Studies May Be Measuring the Wrong Molecule
A new commentary in BMC Cancer warns that pan-cancer studies treating CFH as a single cancer biomarker have been measuring ...
Rare Fusion Gene and WT1 Overexpression Define an Aggressive Leukemia Subtype
A newly reported leukemia case carrying both the rare DEK::CAN fusion gene and WT1 overexpression reveals how genetic synergy and ...
Blocking the Brain’s Cannabis Receptor Repairs Faulty RNA Splicing in Fragile X Mice
A new study in iScience shows that blocking the cannabinoid CB1 receptor with low-dose rimonabant reverses disease-associated alternative splicing defects ...
Long-Read RNA Sequencing Reveals Hidden Isoform Chaos That Gene-Level Cancer Studies Miss
A long-read RNA sequencing atlas of 144 paired tumor-normal samples across ten organs shows that gene expression changes converge across ...
Fly Study Reveals How the RNA Modifier Mettl16 Shapes Development and Fertility
New research in fruit flies shows that the RNA methyltransferase Mettl16 is dispensable for survival but essential for fertility, acting ...
Hidden RNA switches reshape cancer proteins and sabotage drug targets
A comprehensive multi-omics study catalogues thousands of cancer-specific isoform switches in melanoma, ovarian cancer, and AML, showing that most disrupt ...
RNA-Binding RBM Proteins Emerge as Double-Edged Players in Cancer
A new review in Medical Oncology details how the RBM family of RNA-binding proteins acts as both tumor suppressors and ...
Splicing Factor LUC7L2 Emerges as a Driver of Kidney Damage from Chemotherapy
New research reveals that the RNA splicing factor LUC7L2 drives ferroptotic kidney damage from cisplatin by corrupting the splicing of ...
Hidden RNA Switches May Explain How Eucalyptus Leaves Turn Red Under Stress
A new full-length transcriptome study reveals extensive alternative splicing and identifies three MYB113 genes, including the unusual MYB113c, as regulators ...
Splice Variant VEGF165b Emerges as a Natural Shield Against Acute Lung Injury
A newly published study identifies the VEGF-A splice variant VEGF165b as an endogenous protector that shields the lung's blood vessels ...
m6A’s Role in Splicing, Cancer, and Methods
In the rapidly evolving realm of molecular biology, one of the most captivating frontiers is the epitranscriptome—the layer of chemical ...
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