Cancer

A preclinical Mayo Clinic study found that MAPK inhibitors restored TSHR on anaplastic thyroid cancer cells and improved tumor control...

A machine-learning pipeline identified AML-selective small molecules and implicated glutathione reductase as a vulnerability that can be exploited in laboratory...

A peer-reviewed study associated elevated circulating B cells before treatment with increased risk of immune checkpoint inhibitor–related colitis and found...

The Partita CRISPR activation library identified Irx5 as a gene linked to venetoclax resistance and Runx2, Runx3 and Csf1r as...

A preclinical study found that SIRPα signaling inside triple-negative breast cancer cells promoted mitochondrial fission, motility, immune tolerance and brain...

A phase 2 randomized trial found fewer adverse events with daily oral vitamin C in people with pre-leukemia blood disorders,...

A phase 2 randomized trial found favorable biological, clinical and exploratory survival signals from vitamin C in pre-cancer blood disorders,...

A prospective cohort study of 837 colorectal cancer patients linked distinct tumor blood-vessel features with colorectal cancer-specific mortality.

A prospective EPIC-based study found blood-protein associations with prostate cancer more than 15 years before diagnosis, including markers linked to...

A controlled study of mice with tau pathology found that BCG vaccination reduced brain inflammation and tau deposition and improved...

A Johns Hopkins retrospective cohort study found 96% overall survival among 23 children and young adults with severe aplastic anemia...

The fluorescent agent JAS239 identified tumor margins and a hidden lung lesion in a trial involving 20 dogs, while also...

An observational study of more than 200 children and young people found that early response to blinatumomab and leukemia genetics...

A single-patient case report documents delayed toxic epidermal necrolysis after six cycles of pembrolizumab and enfortumab vedotin for metastatic urothelial...

Insilico Medicine plans to present first human Phase 1 data for the AI-designed pan-TEAD inhibitor ISM6331 in mesothelioma and other...

In a study of 349 participants, physician warmth and competence influenced how people interpreted identical normal test results, with high...

Penn Medicine researchers and clinicians will present clinical-trial research, professional priorities and communication strategies at ASTRO’s 68th Annual Meeting in...

An animal study by City of Hope researchers shows that modular CAR T cells can accept engineered adaptors after treatment,...

A new university spin-out is developing steroid-signature tests for adrenal cancer and metabolic ovarian syndrome, with regulatory certification and clinical...

An observational study found hidden immune activity and a distinctive gut environment in bowel disease associated with PSC, offering a...