Biology
Hypercontractile embryos from older female mice experience implantation failure
A hidden mechanical failure inside the earliest stages of life may help explain why fertility declines so sharply as females...
European summit plant communities show widespread thermophilization, weakly linked to climate warming
Europe’s highest plant communities are getting warmer in character, but not necessarily because the climate above them is warming in...
Scientists design tissue-specific mammalian enhancers that function in mouse embryos
A new study reports a step toward treating mammalian gene regulation as an engineering problem: rather than searching through the...
Disrupted Cellular RNA Balance Drives MDA5 Activation During Viral Infection
For decades, antiviral immunity has been described as a molecular surveillance system built to distinguish the genetic material of invading...
Experts develop consensus approach for spatially aware clustering beyond benchmarking
Spatial biology has created a problem that conventional clustering benchmarks were never designed to solve. In technologies such as spatial...
Scientists Identify Factors Governing Human β2-Adrenergic Receptor–β-Arrestin Complex Assembly
A new study published in Nature Structural & Molecular Biology is clarifying how one of the most important signaling complexes...
Benchmarking ESM2 Across Scales for Predicting Viral Entry Proteins
Viral entry proteins are among the most consequential molecules in infectious disease biology. Positioned at the interface between a virus...
Single-cell RNA sequencing maps gonadal changes during sex reversal in orange-spotted grouper
A single-cell transcriptomic study of the orange-spotted grouper, Epinephelus coioides, is offering an unprecedented view of how a fish gonad...
Genomic Study Reveals Diversity, Light-Powered Proteins, and Eight New Aquirufa Species
Freshwater ecosystems are home to an extraordinary fraction of Earth’s microbial diversity, yet many of the bacteria inhabiting rivers, lakes...
Targeting POLG Weakens Breast Cancer Stemness by Disrupting Mitochondrial Function
A new study is drawing attention to a possible metabolic vulnerability in breast cancer stem cells: the mitochondrial DNA maintenance...
Balanced mRNA and ribosome levels govern growth in eukaryotic cells
A new study in budding yeast suggests that one of biology’s most fundamental processes—cell growth—may be governed by a remarkably...
Non-native plants’ mycorrhizal strategies shift across biomes and disturbance levels
A global study has challenged one of ecology’s most persistent assumptions about invasive plants: that their success is consistently powered...
Japanese Colorectal Cancer Reveals Prevalence, Timing, and Microbiome Signatures of Colibactin Mutations
Colorectal cancer is often described as a disease written into the genome, but the authors of a new study argue...
New CAF Population Directs Highly Suppressive Regulatory T Cells in Lung Tumors
A previously unrecognized population of cancer-associated fibroblasts appears to act as a spatial organizer for immune suppression in lung cancer,...
Protein nanocrates overcome air–water interface artifacts in cryo-EM
Cryo-electron microscopy has transformed structural biology by allowing scientists to visualize proteins and other biological machines at near-atomic resolution. Yet...
Nucleosomes and IDRs Restrain GCN4’s Promiscuous Binding on Minichromosomes
A new study is reshaping the way scientists understand how transcription factors find their targets inside the crowded genome. Researchers...
Framework combines multiple evidence streams to discover biomarkers in small-sample time-series transcriptomics
Small-sample RNA-sequencing studies often promise a window into the molecular changes that accompany disease, treatment response, or infection. Yet when...
Photoprotection, carbon reallocation drive Dendropanax trifidus drought recovery in future climates
A subtropical tree has revealed how forests may survive a future defined by hotter temperatures, rising atmospheric carbon dioxide and...
Rainfall Shapes Rhizosphere Microbial Communities Across Two Alpine Wetland Types
Rainfall is doing more than replenishing water in alpine wetlands: it may be steering the microscopic communities that live around...
Hunter-gatherers sleep as long as modern humans, but at different times
The idea that every adult needs exactly eight hours of sleep has become one of modern wellness culture’s most durable...