Preclinical and clinical investigations reveal that the transcription factor TFAP2A enhances radiotherapy resistance in non-small cell lung cancer by directly ...
Overexpressing the LysR transcriptional regulator in Streptomyces albulus significantly enhanced epsilon-poly-L-lysine production in both flask and five-liter bioreactor fermentations under ...
Researchers have discovered HagF, a lineage-specific bacterial protein that counteracts the repressor HrcA to amplify protective chaperone expression and safeguard ...
Researchers have discovered that the Type I-E CRISPR-Cas system functions as a direct transcriptional regulator controlling virulence phenotypes, bile resistance, ...
A new study identifies the AoMYB-like–AoAreB–AoAspB module as a key regulator linking nitrogen availability to spore formation in the nematode-trapping ...
A single promoter SNP that boosts GaOFP17 expression reduces cotton boll and seed sizes by engaging the transcription factor NF-YC4 ...
A new study reports that TROP2 suppresses pyroptosis through the PI3K/AKT pathway, promoting hypopharyngeal squamous cell carcinoma progression.
A new Cell Division study reports that the transcription factor PRRX2 activates the CNTN3 gene, promoting epithelial-to-mesenchymal transition, proliferation and ...
Nuclear L-insert-containing CK1α isoforms act as positive components of the β-catenin/TCF complex, while pharmacological CK1α activation with SSTC3 depletes WNT-driven ...
A new review argues that the NF-κB1 subunit's p105 and p50 proteins act as context-dependent regulators of neuronal survival and ...
An experimental study reports that SP1-induced PDRG1 promotes the proliferation and metastasis of hepatocellular carcinoma by activating the Wnt/β-catenin pathway ...
In preclinical lung squamous cell carcinoma models, GATA6 directly represses BMP2, while elevated BMP2 activates ERK1/2 signaling and promotes tumor-cell ...
A study in Jurkat T cells found that activated STAT3 binds the Ets-2 promoter, reduces expression of a transcriptional silencer, ...
Three WRKY transcription factors activate PsDFR2 and promote anthocyanin accumulation, helping explain the molecular basis of red pigmentation in tree ...
Researchers have catalogued 47 WRKY transcription factor genes in Codonopsis pilosula and linked specific members, including Cpi05G005333-I, to the herb's ...
A short isoform of the BRD4 protein helps gastric cancer cells resist ferroptotic cell death by sustaining glutathione production, thereby ...
Researchers at South China Agricultural University report that the soybean VQ motif gene GmVQ32 enhances tolerance to both aluminium toxicity ...
New research reveals how nitrogen starvation, a cryptochrome photoreceptor, and humidity checkpoints govern the transcriptional program that drives spore formation ...
Researchers identified the GRAS transcription factor PmGRAS8 as a candidate activator of the phosphate-responsive PmSPX1 promoter in Masson pine, shedding ...
A new study shows that the transcription factor ELF4 activates the enzyme UGT8, reshaping sphingolipid metabolism to drive esophageal squamous ...
