Tag: T cell exhaustion

Researchers found that elevated TMC8 expression in clear cell renal cell carcinoma correlates with poor survival, paradoxical immune infiltration, and ...

NUS Medicine researchers found that the protein DUSP4 helps CD8+ T cells retain their cancer-killing function and that boosting its ...

A new study shows that SMARCAL1 forms nuclear condensates that reprogram chromatin and methionine metabolism, weakening radiotherapy and immunotherapy responses.

Researchers report that the epigenetic regulator BAZ2A drives renal cancer cells to accumulate palmitic acid, which impairs CAR-T cell mitochondria ...

A new review maps how African swine fever virus dismantles interferon signaling, inflammatory pathways, antigen presentation and lymphocyte function, explaining ...

A new review details how tumor cells import, export and steal mitochondria through nanotubes and vesicles to fuel growth, exhaust ...

A mouse study found that PCV2d infection activated lymphocyte subsets on distinct schedules, triggered thymic T-cell apoptosis, shifted memory T-cell ...

Blocking the CD276 molecule slowed gastric cancer growth and, combined with anti-PD-1 therapy, produced the strongest tumor suppression and increased ...

A new review finds checkpoint inhibitors are safe and effective for virologically suppressed people with HIV, while sub-Saharan Africa remains ...

A BMC Medicine debate article argues that T cells in acute myeloid leukemia are not uniformly dysfunctional and that assessing ...

A controlled syngeneic mouse study found that intracranial A20 B-cell lymphoma had stronger T-cell exhaustion, regulatory-cell expansion and dendritic-cell immunoregulation ...

St. Jude scientists found that deleting the gene ZMYND8 relieves CD8-positive T-cell exhaustion and synergizes with immunotherapy to improve anti-tumor ...

A systematic bibliometric review of more than 3,200 publications reveals that tumor immunometabolism research has surged since 2020, shifting from ...

Single-cell sequencing reveals that self-derived and donor-derived exhausted T cells in acute myeloid leukemia run on different transcriptional programs, with ...

A sweeping new review in Molecular Cancer maps the PD-1/PD-L1 axis from immune evasion mechanisms to next-generation therapeutics, offering a ...

UCLA researchers used a genome-wide CRISPR screen to identify the Cullin-5 RING E3 ligase complex as a key driver of ...

A new computational framework called SDSGI uncovers subtype-specific long non-coding RNAs in tumor-infiltrating CD8-positive T cells across multiple cancer types, ...

New research shows that inhibiting the FGFR signaling pathway reduces T cell exhaustion and repolarizes macrophages, significantly enhancing PD-1 blockade ...

A single-cell multi-omic atlas of neuroendocrine carcinoma of the cervix identifies DLL3 as a driver of immune evasion and validates ...

Untargeted metabolomics of Ebola survivors in Sierra Leone reveals that those with post-Ebola syndrome show broad downregulation of TCA cycle, ...