Tag: T cell exhaustion

A single-cell multi-omic atlas of neuroendocrine carcinoma of the cervix identifies DLL3 as a driver of immune evasion and validates ...

Untargeted metabolomics of Ebola survivors in Sierra Leone reveals that those with post-Ebola syndrome show broad downregulation of TCA cycle, ...

A new review synthesizes single-cell chromatin accessibility studies showing that colorectal cancer is organized into two epigenomic states whose regulatory ...

A pan-cancer single-cell atlas of nearly 900,000 cells shows that bone metastases from ten cancer types share convergent malignant programs ...

Wistar Institute scientists report that combining the kidney cancer drug axitinib with a 4-1BB agonist overcame myeloid cell suppression and ...

A new review in Molecular Cancer explains how tumor-derived exosomes act as mobile signaling hubs that spread immune suppression, drive ...

A new review in Medical Oncology maps how the tumor microenvironment and gut microbiome drive resistance to immune checkpoint inhibitors ...

A new study shows that the protein SIRPα, produced by esophageal cancer cells themselves, fuels both tumor growth and T-cell ...

Single-cell analysis of 56 glioblastoma tumors reveals that T-cell-rich cases harbor clonally expanded, LAG3-high CD8 T cells that may be ...

A new analysis suggests HIV impairs the immune system's ability to recognize tumor neoantigens in non-small cell lung cancer without ...

In the relentless quest to harness the immune system’s power to combat cancer, chimeric antigen receptor T cell (CAR-T) therapy ...

In a groundbreaking exploration of immune regulation, recent research unveils the critical role of the ubiquitin ligase KLHL6 in modulating ...

In the field of cancer research, the complexities of immunology and metabolism present a fascinating but daunting landscape. Recent findings ...

In the relentless battle against cancer, T cells have emerged as pivotal warriors within the adaptive immune system. These specialized ...

In a dramatic revelation that challenges conventional thinking about cell biology, scientists report that cancer cells can effectively “poison” the ...