Zebrafish Study Points to tnni2a.3 as a Candidate Gene in Intermuscular Bone Formation
A spatial transcriptomic atlas of zebrafish muscle tissue identifies tnni2a.3 as a candidate gene associated with intermuscular bone formation, with ...
Tag: Spatial transcriptomics
Dietary restriction reshapes melanoma immune landscape and may boost immunotherapy response
A transcriptomic study links dietary restriction-associated immune and vascular changes in melanoma tumors to better prognosis and improved immunotherapy response.
New Tool Maps Tissue Regions by Cell Type Composition
A new computational method called concordex identifies tissue regions homogeneous in cell type composition, helping separate true spatial gene expression ...
B Cell Depletion Marks High-Risk Hodgkin Lymphoma, Spatial Study Finds
A spatial transcriptomics study links depletion of non-tumoral B cells to relapse risk in classical Hodgkin lymphoma and introduces an ...
H&E Slide Spatial Features Explain Gene Expression Beyond Cell-Type Mix
Spatial features extracted from routine H&E slides of 471 normal prostate tissue samples significantly improved gene expression models for 2,330 ...
New BLASE tool maps bulk RNA-seq samples onto single-cell trajectories
A new open-source R package called BLASE maps bulk RNA-seq samples onto single-cell pseudotime trajectories, outperforming existing deconvolution tools in ...
New computational tool unearths hidden cell-type signals in bulk and spatial transcriptomics
A benchmarked computational framework called BayesPrism-DWLS infers cell-type proportions and cell-type-specific gene expression from bulk RNA-seq and spatial transcriptomics data ...
Endothelial ICAM-1 Polarization Traps T Cells at Melanoma Tumor Edges
Endothelial ICAM-1 becomes polarized to the tumor periphery as melanomas grow, trapping T cells at the margins, and blocking it ...
RNA positions in the breast tumor microenvironment linked to DCIS progression and recurrence
A study of breast tissue microarrays mapped where regulatory RNAs and stromal proteins sit within benign, DCIS and invasive lesions, ...
Research report: Single-cell insights into plant responses to biotic and abiotic stresses: cellular heterogeneity and regulatory mechanisms
A new review in Plant Cell Reports synthesizes how single-cell and spatial omics technologies reveal distinct cellular strategies plants use ...
Immune-cell study hints IL-1β macrophages may fuel pro-tumor signals in liver cancer
Single-cell and multi-omics analyses of hepatocellular carcinoma point to IL-1β-positive macrophages and IL-1R1-positive inflammatory fibroblasts as putative drivers of a ...
CXCR4 emerges as a dermal immune signal hub in psoriasis, single-cell and spatial study finds
An integrated single-cell and spatial transcriptomics study finds CXCR4 concentrated in dermal immune cells of psoriatic skin and identifies a ...
New CSDE method corrects preprocessing bias in spatial transcriptomics
A new method called CSDE uses a small set of expert-validated cells to correct systematic preprocessing errors in spatial transcriptomics ...
Tumor cell program tied to lymphatic responses in aggressive thyroid cancer
A multi-omics study links an extracellular matrix-associated epithelial state and a SERPINA1–SOX4–FN1 molecular axis to lymphatic endothelial responses in papillary ...
Gastric Cancer’s Public Data Boom Produces Gene Lists, Not Clinical Answers, Review Warns
A sweeping methodological review published in Frontiers in Oncology argues that the explosion of public-omics research in gastric cancer has ...
GSTK1 Ties Inflammation, Glycolysis, and Lactylation in Gastric Cancer
Integrated transcriptomic and cell-line analyses link GSTK1 expression to favorable gastric cancer prognosis and to IL-6/JAK2/STAT3 signaling, glycolysis-related proteins, and ...
Epigenetic YAP1–TEAD–TET1 pathway drives liver cancer without driver mutations
A mouse study from Institute of Science Tokyo shows the YAP1–TEAD–TET1 epigenetic pathway can drive hepatocellular carcinoma without canonical driver ...
Spatial gene map reveals compartment-specific reprogramming in inflamed fatty livers
A spatial transcriptomics study of 16 MASH patients and eight controls maps compartment-specific CYP450 suppression, immune activation, and disrupted cell-cell ...
Osteosarcoma rewires matrix signaling as disease progresses
A 2026 Review argues that osteosarcoma survival and lung spread depend on stage-specific rewiring of extracellular-matrix signaling rather than one ...
AI Maps Glioma Ecosystems and Exposes a Macrophage-Driven Vulnerability in Glioblastoma
An AI-driven single-cell and spatial multi-omics study defines three glioma ecosystem states and shows that a hypoxic myeloid-mesenchymal state independently ...
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