Tag: Spatial transcriptomics

Researchers introduced SWIMR, a statistical framework that integrates multiple single-cell RNA sequencing references to improve cell-type deconvolution accuracy in spatial ...

An integrative hypothesis-generating analysis identified SPP1 and extracellular matrix remodeling as candidate features linking bisphenol A exposure to an immunosuppressive ...

Spatial profiling of melanoma tumors reveals that lipid-associated macrophage neighborhoods drive immune exclusion and predict resistance to checkpoint inhibitor therapy.

A study integrating spatial transcriptomics, single-cell RNA sequencing and a 27-patient clinical cohort links peritumoral tertiary lymphoid structures and high ...

Single-cell and spatial transcriptomics of mouse skin tumors reveal that myeloid-derived oncostatin M and TGFβ1 establish distinct stromal niches that ...

Researchers have identified a JUN-dependent MIF transcriptional program linked to a secretory epithelial cell state and predicted myeloid interactions in ...

A sequential regimen combining chemical carcinogens and a Western diet reliably produces advanced hepatocellular carcinoma in male and female mice ...

Integrated single-nucleus and spatial transcriptomics of 43 choroid plexus tumours reveal ten tumour metaprograms that cluster by methylation subtype and ...

Researchers report that stromal APOL4 marks a distinct cancer-associated fibroblast state whose loss confers carboplatin resistance in ovarian cancer co-cultures ...

A new review maps the biomarkers, transcriptomic signatures and methodological pitfalls involved in reliably identifying senescent vascular smooth muscle cells ...

A SCGB3A2-high tumor cell state in lung adenocarcinoma shows low angiogenesis and is associated with extracellular PGK2 and angiostatin signals.

Researchers have introduced CORAL, a probabilistic deep generative model that leverages graph attention to integrate multiscale spatial transcriptomic, proteomic, metabolomic, ...

A cross-species co-expression analysis of Pkd1-mutant mouse kidneys found circadian, sterol and mitochondrial modules deregulated weeks before cysts appeared.

Two studies show glioblastoma cells follow predictable paths between states, and reprogramming a single regulator improved survival in mouse models.

The ATLAS method imputes spatial single-cell maps of mouse brains and uncovers cell-type and regional composition differences between sexes and ...

A new Brain Informatics review traces how AI methods, from co-expression statistics to causal graph neural networks and foundation models, ...

A new review argues that stem cell grafts can protect tissue and communicate with host circuits in selected spinal cord ...

Single-cell and spatial profiling of pancreatic tumors reveals a reinforcing loop between mature dendritic cells and regulatory T cells, mediated ...

A new electrospun membrane loaded with ibuprofen reduced ureteral fibrosis and obstruction-related dilation in rabbits when applied immediately after thermal ...

A Cell & Bioscience study links compartment-specific AKAP12 promoter methylation to opposing epithelial and stromal programs in colorectal cancer and ...