Plasma GDF15 Shows Diagnostic Potential in Biopsy-Indicated Prostate Cancer Cohort
A biopsy-indicated cohort study found plasma GDF15 achieved an AUC of 0.805 for prostate cancer detection, and a nomogram combining ...
Tag: Proteomics
Blood proteins may expose hidden heart risk that standard scores miss
A PLOS Medicine Perspective argues that cardiovascular risk prediction is advancing on two fronts, using blood-based protein signatures and other ...
Rat study maps gene and protein shifts in brown fat during cold acclimatization
A combined transcriptomic and proteomic analysis of brown adipose tissue in cold-exposed rats identified thousands of gene and protein expression ...
New Method Maps the Fatty Landscape of the Cell’s Protein Factory
A new immunoisolation method called mammalian MemPrep delivers a high-confidence lipid and protein inventory of the endoplasmic reticulum in HEK293T ...
Heart’s Resident Cells, Not Immune Cells, Drive Damage After Heart Attacks
A bone marrow chimera study in mice shows that deleting the CLEC4E receptor in cardiac resident cells, rather than in ...
Engineered vesicles deliver miR-204 to triple-negative breast cancer cells in preclinical tests
Researchers engineered GE11-targeted vesicles that delivered tumor-suppressive miR-204 into EGFR1-positive triple-negative breast cancer cells, inhibiting their growth in lab and ...
Processed diets tied to gestational diabetes and altered blood proteins in Miao women
A matched case-control study of 78 Miao pregnant women in Guizhou, China, linked a processed dietary pattern to higher odds ...
Cancer cells on the move shed giant vesicles packed with whole genomes
Migrating cancer cells shed large vesicles called MoVes that carry whole genomic DNA, organelles and EMT-linked proteins, according to a ...
New Mouse Model Reveals How RMND1 Mutations Disrupt Mitochondrial Energy Production
The first knock-in mouse carrying the recurrent human RMND1 p.(Asn238Ser) mutation recapitulates severe multisystem mitochondrial disease, revealing widespread OXPHOS defects ...
Witnessing Defeat Is Not the Same as Suffering It: Mouse Study Shows Two Stress Models Diverge
A controlled mouse study finds that witnessed social defeat produces overlapping but distinct behavioral and hippocampal molecular effects from direct ...
Parasite Larvae and Their Vesicles Push Gut Cells in Opposite Directions in Lab Study
In laboratory experiments, live Strongyloides stercoralis larvae triggered pro-inflammatory responses in human intestinal epithelial cells while the parasites' extracellular vesicles ...
E3 Ligase UBE4B Tags VPS35 for Destruction, Steering Cancer Cell Behavior in Context-Dependent Ways
A new study shows the E3 ligase UBE4B ubiquitinates and degrades VPS35, with opposing effects on cancer cell proliferation and ...
CSF Protein Signals Stay Stable Through Repeated Freeze-Thaw Cycles in High-Throughput Assay Test
A new evaluation of the Olink Explore 3072 proximity extension assay in cerebrospinal fluid finds that protein detectability and variability ...
SPF Pig Tendons Turned Into Decellularized Biomaterial for Repair Research
Scientists optimized a decellularization protocol for SPF porcine tendons and characterized a biocompatible tendon matrix membrane in vitro and in ...
Research report: Short-interval variability and test-retest reliability of Alzheimer’s disease plasma biomarkers in a clinically heterogenous cohort
A UCL study of 92 participants found core Alzheimer's plasma biomarkers showed high test-retest reliability over intervals from 30 minutes ...
Blood Protein Signatures Refine Cardiovascular Risk Prediction in Cohort Study
Protein risk scores built from 14 blood proteins each improved cardiovascular risk classification beyond traditional scores in a Chinese community ...
Blood protein signatures may hint at which rheumatoid arthritis drug will work first
An exploratory study derived drug-specific protein signatures from rheumatoid arthritis immune cells ex vivo and found they moderately discriminated treatment-specific ...
R-propranolol shows strongest anti-angiogenic effect in infantile haemangioma cell model
In a three-dimensional laboratory model of infantile haemangioma endothelial cells, R-propranolol suppressed sprouting angiogenesis and angiogenic factor secretion more strongly ...
Proteasome inhibitor primes temozolomide response in a molecular subset of recurrent glioblastoma
An interim analysis of the BORTEM-17 phase IB/II trial found that sequential bortezomib and temozolomide achieved disease control in four ...
Protein maps trace how liver, lung and spleen respond to disseminated Talaromyces marneffei infection
An organ-resolved proteomic study in mice maps shared and organ-specific host responses to disseminated Talaromyces marneffei infection.
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