Tag: PI3K/AKT pathway

A traditional Chinese medicine formula reduced liver fibrosis in rat and cell models by down-regulating the PI3K/AKT signaling pathway, according ...

A new review finds that the traditional Chinese fruit Yi Zhi Ren shows broad neuroprotective and metabolic activity in cell ...

A network pharmacology and rat study found that the traditional Chinese formula Zhizhu Decoction improved constipation-predominant IBS-like symptoms, intestinal barrier ...

A laboratory study finds that Th17-derived IL-17 signaling activates AKT in cervical carcinoma cell lines, reducing their sensitivity to cisplatin, ...

A multi-omics and in vitro study finds BUB1 overexpressed in endometrial carcinoma, linked to poor survival, and suppressible by the ...

A cell-culture study found that cannabinoid receptor 1, highly expressed in rheumatoid arthritis synovial tissue, restrains fibroblast-like synoviocyte proliferation, invasion, ...

Researchers report that reduced BMP8B expression in preeclamptic placentas may impair trophoblast invasion through the BMP8B–SULF2 signaling axis.

A combined bioinformatics and experimental study finds that the potassium channel KCNH8 is reduced in breast tumors and restrains triple-negative ...

A new study reports that the protein STOML2 is overexpressed in hepatocellular carcinoma and that silencing it in a liver ...

A Mendelian randomization study combined with tumor database and cell experiments links genetically higher serum uric acid to lower gastric ...

A machine learning model built from single-cell data stratifies osteosarcoma patients by survival risk and identifies OPN3 as a candidate ...

A rat study finds that low-dose tacrolimus lowered right ventricular pressure and reduced pulmonary vascular remodeling through endothelial protection and ...

Whole exome sequencing of a Chinese diabetes pedigree identified rare EPHX3 and FHOD1 variants carried by all five affected members ...

New research links elevated SPOCK1 levels to significantly reduced overall survival in head and neck squamous cell carcinomas, suggesting aggressive ...

A marine-derived fungal sesterterpenoid called MHO7 suppresses the migration and invasion of triple-negative breast cancer cells by inhibiting the FAK ...

A ginseng-derived saponin suppresses pancreatic cancer in preclinical models by blocking the PI3K-AKT pathway and preventing macrophages from adopting a ...

A new mouse study shows that bone marrow mesenchymal stem cells treat chemotherapy-induced premature ovarian failure by rebalancing the Bcl2/Caspase3 ...

New research shows that the metabolic protein ANGPTL8 drives the aging of hematopoietic stem and progenitor cells by binding the ...

A new study shows that the Pongamia pinnata-derived flavonoid karanjin selectively kills breast, lung, and colorectal cancer cells by inducing ...

New research shows that the protein UBAP2L is essential for neural progenitor cell division, and that its loss in mice ...