Phosphorylation of 14-3-3γ Impairs Its Ability to Limit Alpha-Synuclein Aggregation
A new study reveals that Ser59 phosphorylation impairs the protective ability of 14-3-3γ against alpha-synuclein aggregation and reshapes its global ...
Tag: phosphorylation
Cell-cycle kinase CDK4 keeps breast cancer cells mechanically stable, study finds
Scientists report that the cell-cycle kinase CDK4 keeps triple-negative breast cancer cells mechanically stable by phosphorylating Myo9b at serine 1935, ...
Research report: Differential phosphorylation of PHIP phosphopeptides with implications in insulin signaling
A large-scale integration of human phosphoproteomics datasets identifies seven predominant phosphorylation sites on PHIP and links their co-regulation to insulin ...
MDM4 stabilizes a glycolytic enzyme to fuel growth in TP53-mutant oral cancer
A new study reports that MDM4 promotes glycolysis and proliferation in TP53-mutant oral squamous cell carcinoma by stabilizing the enzyme ...
Springtail Hox Protein Reveals Evolutionary Middle Ground in Losing Abdominal Limbs
A study of the springtail Folsomia candida shows that its Ubx protein binds and represses the appendage gene Dll like ...
Pan-Cancer Analysis Maps PTPN3’s Contrasting Roles Across Tumors
A multi-platform pan-cancer analysis finds PTPN3 shows cancer-type-dependent differences in expression, survival associations, genomic alterations, phosphorylation and stromal correlations.
PLK1’s Hidden Code: How Chemical Tags Orchestrate Cell Division and Cancer
A new review synthesizes how phosphorylation, ubiquitination, methylation, SUMOylation and O-GlcNAcylation form an interconnected network that controls the mitotic kinase ...
Src kinase emerges as a molecular player in early tau pathology in Alzheimer’s disease
A new study links upregulated Src kinase and the transcription factor NEUROD2 to early tau pathology in Alzheimer's disease, supported ...
Study maps phosphorylation network linking MLLT1 to transcriptional control in cancers
An integrative analysis identified key MLLT1 phosphorylation sites and a co-phosphoregulated network linked to transcriptional elongation and chromatin regulation in ...
Single phosphorylation event controls where NMDA receptors sit in the brain
A new Nature Neuroscience study shows that SIK3 phosphorylates GluN1 at a single site to control the recruitment of NMDA ...
Lck kinase fine-tunes T cell activation by phosphorylating autophagy receptor p62
A new EMBO Reports study shows that the kinase Lck phosphorylates the autophagy receptor p62 at tyrosine 433 within minutes ...
Pepper kinase CaSNF1 phosphorylates CaHD-ZIP to boost cold tolerance
A pepper study identifies CaSNF1 as a kinase that interacts with and phosphorylates the transcription factor CaHD-ZIP, revealing a regulatory ...
Massive Phosphoproteomics Sweep Maps the Hidden Regulatory Switches on a Key Metabolic Enzyme
An integrative analysis of more than 2,300 human phosphoproteomics datasets identifies serines 168, 169 and 189 as the predominant phosphorylation ...
Two Kinases Keep the Fly Circadian Clock on Time When Temperatures Shift
A genetic study in Drosophila shows that the conserved kinases CK2 and DBT preserve circadian temperature compensation through distinct phosphorylation ...
Phosphate tweak turns macadamia waste protein into a powerful emulsion stabilizer
Phosphorylation with sodium tripolyphosphate raised the solubility of macadamia protein isolate from about 14 percent to nearly 97 percent and ...
The Tumor Suppressor CYLD: A Molecular Switchboard Controlled by Chemical Tags
A new review reveals how the tumor suppressor and deubiquitinating enzyme CYLD is switched on and off by phosphorylation, ubiquitination, ...
Hidden Protein Switches That Keep Bones in Balance May Reshape Osteoporosis Research
A new BMC Medicine review maps how post-translational modifications act as a networked control layer that gates, amplifies, and dampens ...
Scaffold Protein LAMB1 Drives Esophageal Cancer Growth Through JAK2/STAT3 Pathway
New research shows that the extracellular matrix protein LAMB1 accelerates esophageal squamous cell carcinoma by activating JAK2/STAT3 signaling, suggesting it ...
Hidden RNA Molecule Drives Ovarian Cancer Growth by Activating Key Stress Pathway
Researchers found that the long non-coding RNA ATP6V1B1-AS1 promotes ovarian cancer growth and metastasis by binding MAP3K3 and activating the ...
The Phosphatase Switch: How PP2Acα Emerges as a Drug Target for Inflammatory Bowel Disease
A new review argues that the phosphorylation-dephosphorylation balance controlled largely by the phosphatase PP2Acα acts as a master switch in ...
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