Tag: Mitochondrial dysfunction

A narrative review finds that naringenin and naringin counter bisphenol A–related male reproductive injury in cell and animal models, but ...

Mitochondria and lysosomes talk to each other, and sepsis may break that conversation

A new narrative review argues that disrupted communication between mitochondria and lysosomes may offer an organizing framework for understanding sepsis-induced ...

Beyond Blood Sugar: How Type 2 Diabetes Research Is Being Rewritten

A new narrative review argues that chronic inflammation, gut microbiota dysbiosis, and mitochondrial dysfunction are reshaping type 2 diabetes care ...

Oligodendroglial Alpha-Synuclein Rewires Midbrain Gene Programs Before Nigral Cell Loss in Mouse Model of MSA

In a mouse model of multiple system atrophy, oligodendroglial alpha-synuclein drives early ventral midbrain transcriptional changes in mitochondrial, metabolic and ...

Astrocyte Stress Protein NDRG2 Emerges as a Candidate Target in Depression Review

A new review proposes that the astrocytic stress-responsive protein NDRG2 coordinates multiple depression-related pathways and may serve as a precise ...

Salidroside Protects Bovine Mammary Cells From Inflammation by Activating Mitophagy

A new cell-culture study reports that salidroside protects bovine mammary epithelial cells from LPS-induced inflammatory injury by activating AMPK/mTOR signaling ...

Can Metabolic Supplements Slow Retinal Aging? Review Weighs the Evidence

A new review finds that while AREDS formulations remain the only well-established nutritional therapy for retinal disease, NAD+ boosters, citicoline, ...

Mitochondrial Transfer Emerges as a Therapeutic Strategy for Cardiovascular Disease

A new open-access review maps how mitochondrial transfer and transplantation could treat cardiovascular diseases, from cellular mechanisms to early clinical ...

Mitochondrial dysfunction emerges as a shared thread across neurological disease

A new review in Nature Reviews Neurology outlines how mitochondrial biomarkers spanning fluid, genetic, multi-omics and imaging domains could aid ...

Obesity May Harm Sperm Motility Through a STAT3/MTND4 Mitochondrial Pathway in Mice

A mouse and cell study reports that STAT3 transcriptionally activates MTND4, driving ROS production and mitochondrial dysfunction linked to obesity-related ...

mTORC1 may act as a transition switch in ME/CFS post-exertional malaise

A new review proposes mTORC1 as a transition switch linking mitochondrial dysfunction to post-exertional malaise in ME/CFS, while noting that ...

Fatty Diet Leaves Lasting Senescence-Like Scars in the Liver’s Regenerative Cells

A rat study finds that chronic high-fat diet feeding leaves liver organoid-forming regenerative cells locked in a senescence-like state with ...

High-Salt Diet Impairs Memory in Aged Mice by Overwhelming Mitochondrial Cleanup

A two-month high-salt diet impaired learning and memory in aged male mice and increased amyloid-beta accumulation, activating a PINK1/Parkin mitophagy ...

Cell Death Protein MLKL Emerges as Unexpected Driver of Obesity-Linked Liver Cancer

University of Oklahoma researchers report that MLKL, a protein best known for its role in necroptotic cell death, promotes obesity-related ...

Review Proposes Chronic DNA Damage Signaling as an Aging Framework

A peer-reviewed review proposes that chronic DNA damage response signaling may connect senescence, inflammation and other aging processes, while emphasizing ...

Lactate modification drives mitochondrial damage and fibrosis in diabetic hearts