Alzheimer’s Researchers Propose Mitochondrial PINK1 as an “Amyloid Switch” in Disease Pathogenesis
A new commentary proposes that the mitochondrial protein PINK1, a central regulator of mitophagy, could act as a direct amyloid ...
Tag: Mitochondrial dysfunction
FLASH radiotherapy spares healthy astrocytes while stressing glioma cells
A new Cell Death Discovery study shows FLASH radiotherapy preserves mitochondrial function in healthy astrocytes while driving sustained redox and ...
CaMKII Emerges as Central Molecular Hub Driving the Ageing Heart
A new review synthesizes preclinical evidence that the CaMKIIδ kinase integrates calcium dysregulation, inflammation, autophagy failure, mitochondrial decline and DNA ...
CMPK2–mtDNA Axis Drives Doxorubicin Heart Damage, Study Finds
A mouse study identifies the mitochondrial enzyme CMPK2 as a key mediator of doxorubicin heart injury and reports that flavin ...
Plant compounds may rewire immune metabolism in heart disease, evidence still thin
A new review maps how plant-derived compounds might modulate immune-cell metabolism in cardiovascular disease, while stressing that most evidence remains ...
Cannabidiol shows preclinical promise against Alzheimer’s disease, but key evidence gaps remain
A new review finds cannabidiol consistently reduces neuroinflammation and oxidative stress in Alzheimer's preclinical models, but evidence for amyloid, tau, ...
Mushrooms and the Molecules of Longevity: What the Evidence Really Shows
A new review argues that mushrooms and the antioxidant L-ergothioneine show anti-aging effects in laboratory models, while human evidence remains ...
Epigenetic ‘metabolic memory’ may keep injuring the diabetic heart after blood sugar improves
A new review in Clinical Epigenetics distinguishes epigenetic changes proven to persist after glycemic normalization in diabetic cardiomyopathy from those ...
Natural Products Target Mitochondria and Macrophage Crosstalk in Kidney Disease Review
A new review examines how mitochondrial dysfunction and macrophage inflammation interact in diabetic nephropathy and whether natural products can modulate ...
Nanoparticle drug delivery shows promise for shielding the heart from doxorubicin
A new review in Cardio-Oncology outlines how nanoparticle drug delivery systems could reduce doxorubicin-induced cardiotoxicity while preserving antitumor efficacy.
Multi-omics review maps molecular pathways tied to recurrent implantation failure
A systematic review of post-2017 multi-omics studies identifies three recurring molecular themes in recurrent implantation failure but concludes no single ...
Perifosine disrupts iron and copper balance, slowing growth in fruit flies
A Drosophila study reports that developmental exposure to perifosine causes growth retardation by disrupting iron and copper homeostasis, with quercetin ...
Iron Overload, Ferroptosis and the Liver: Mapping a Deadly Network
A new review maps how disrupted iron homeostasis and ferroptosis drive liver disease, from hereditary hemochromatosis to hepatocellular carcinoma, and ...
Muscle repair gene CSRP3 works in pigs but not mice, study finds
A new study shows the CSRP3 gene is essential for satellite cell differentiation and muscle regeneration in pigs but dispensable ...
Metabolic Protein Tags Emerge as Key Players in Disc Degeneration
A new review maps how metabolite-driven protein modifications such as lactylation, O-GlcNAcylation and succinylation may link the disc's harsh metabolic ...
Micro- and Nanoplastics May Harm Oocytes Through Oxidative Stress and Endocrine Disruption, Review Finds
A new review synthesizes animal and human evidence suggesting that micro- and nanoplastics may impair oocyte development through several molecular ...
HbA1c Tracks Blood Sugar, Not Muscle Health, in Type 2 Diabetes
A structured narrative review of 30 clinical reports finds that HbA1c's relationship with skeletal muscle health in type 2 diabetes ...
Mitochondrial Protein SYNJ2BP Emerges as Candidate Driver of Muscle Wasting in Experimental Models
Researchers report that SYNJ2BP rises in atrophied human and mouse supraspinatus muscle and that local knockdown attenuated muscle wasting in ...
Mitochondria-Targeting Molecule Weakens Stem-Like Traits and Boosts Cisplatin Response in Lung Cancer Cell Model
A cell-culture study reports that a mitochondria-targeting molecule, PNA-TPP, was associated with Drp1-related mitochondrial dysfunction, weakened stem-like phenotypes and an ...
Damaged Mitochondria and Runaway Glycolysis Reshape Immune Responses, Review Finds
A new review proposes that compensatory upregulation of fermentative glycolysis following mitochondrial dysfunction integrates and modulates the immune responses triggered ...
POPULAR NEWS
-
Two C3 Gene Variants Reveal Functional Independence Between Extracellular and Intracellular Forms of Complement C3
-
Nearly Half of Stroke Patients in Africa and Asia Show Low HDL Cholesterol
-
German heat-health plans rarely evaluated due to political and structural barriers, study finds
-
Carb Quality Beats Glycemic Index in Sperm DNA Study