Tag: microglia

A new mouse study shows that a prior H1N1pdm influenza infection reshapes social, affective, and memory behavior and intensifies neuroinflammation ...

Scientists have discovered that an aging-induced secreted phospholipase called PLA2G2F acts as a neuron-derived signal that protects synapses, calms inflammatory ...

A time-resolved study of CYFIP2 Arg87Cys mice reveals that the seizure-free interval in West syndrome is a period of active ...

A new study identifies CYLD as a deubiquitinase that stabilizes microglial IKKβ, driving NF-κB–NLRP3 signaling, neuronal pyroptosis, and cognitive decline ...

A PLOS Biology Perspective argues that immune and vascular cells, especially microglia, must be core components of neural organoids used ...

A new narrative review maps the complex, context-dependent crosstalk between neurotransmitter systems and the NLRP3 inflammasome, revealing bidirectional regulation with ...

A multiomic study in PLOS Pathogens shows that intranasal HSV-1 infection drives localized, interferon-dominated remodeling of microglia in discrete brainstem ...

A new review charts how stem cell-derived human microglia, brain organoids and chimeric mice are overcoming the genetic and environmental ...

New research shows that the Alzheimer's risk gene BIN1 acts as a brake on microglial inflammation, and its loss exaggerates ...

A new review examines how trogocytosis, the process by which cells nibble membrane fragments from one another, shapes immune regulation, ...

A large postmortem study identified 107 brain DNA methylation sites linked to Alzheimer's pathology and showed that methylation partially mediates ...

University of Oxford researchers have discovered that a specialised population of human microglia protects dopamine neurons in Parkinson's disease by ...

Scientists have engineered an MG1 peptide-targeted liposome that delivers aspirin-triggered resolvin D1 to spinal microglia, reprogramming them via a newly ...

A new mouse study shows that activating the cGAS-STING immune pathway early after spinal cord injury and inhibiting it later ...

A spatial multi-omics study in Nature Communications identifies disease-associated oligodendrocytes whose interleukin 33–ST2 signaling influences alpha-synuclein burden and motor symptoms ...

A Chonnam National University study found that the human dental pulp stem cell secretome reduced oxidative stress and neuroinflammation while ...

A new preclinical study shows that trigonelline, a coffee-derived alkaloid, reduces alpha-synuclein pathology and neuroinflammation in Parkinson's model mice while ...

Scientists have engineered human stem cell-derived spheroids containing myelinating oligodendrocytes and reactive microglia that model demyelination and successful remyelination, offering ...

A single-nucleus atlas of 5.6 million brain cells from 1,384 donors maps cell-type-specific genetic regulation underlying Alzheimer's disease, schizophrenia and ...

An international team led by the University of Malaga has shown in animal models that a prior traumatic brain injury ...