Tag: Metformin

A randomized open-label trial found myo-inositol and metformin both improved menstrual cyclicity in women with insulin-resistant PMOS, while differing in ...

Researchers kept human fibroblasts in a non-dividing state for six months and found that epigenetic and transcriptomic aging clocks accelerated ...

A preclinical study reveals that an ethanolic extract of Thymus vulgaris leaves modulates ovarian gene expression of inhibins and aromatase ...

A new mouse study found that combining metformin with vitamin D3 produced the largest observed improvements in blood glucose, body ...

A validated HPTLC method simultaneously quantifies metformin, dapagliflozin, and glimepiride in a fixed-dose diabetes tablet while tracking their degradation under ...

A randomized crossover trial in healthy Chinese adults found that extended-release reduced-mass metformin tablets made in a new Chinese facility ...

A phase III trial in India found that a single-tablet combination of dapagliflozin, glimepiride, and metformin significantly outperformed co-administered glimepiride ...

Researchers found that elevated prostaglandin E2 triggers early macrophage senescence that spreads to uterine fibroblasts through IL-1beta signaling, driving fibrosis ...

A scoping review of 65 sources finds that PPIs, SGLT2 inhibitors, diuretics and metformin act on magnesium and other micronutrients ...

A six-month observational study of 252 patients in Bengaluru found that a single-pill combination of sitagliptin, dapagliflozin and metformin was ...

Heart muscle cells grown from lung cancer patients reproduce individual susceptibility to osimertinib-induced cardiac dysfunction, with impaired AMPK–LKB1 signaling marking ...

A colon-targeted sodium butyrate microsphere formulation raised fecal butyrate, lowered blood glucose and HOMA-IR, and reduced serum IL-6 in diabetic ...

A rat study found that biological sex modified both radiation-induced lung injury patterns and the effectiveness of enalapril, metformin and ...

A combination of low-dose metformin and valproic acid reprograms the metabolism of drug-tolerant persister cells in gastric and liver cancer ...

A laboratory study in immortalized human chondrocytes reports that high concentrations of metformin trigger caspase- and ROS-dependent apoptosis in senescent ...

A new narrative review argues that chronic inflammation, gut microbiota dysbiosis, and mitochondrial dysfunction are reshaping type 2 diabetes care ...

A preclinical study links elevated NDUFS1, a mitochondrial complex I subunit, to breast cancer progression through increased respiration and PROX1–c-Myc ...

A small randomized trial sub-study found no significant individual-gene changes after 18 months of metformin in older adults with age-related ...

A retrospective study of 919 women found that a multidisciplinary telehealth platform produced significant improvements in insulin resistance, liver enzymes ...

A new integrative review synthesizes 31 human studies showing how transporter, enzyme and target gene variants shape individual responses to ...