Tag: MASLD

A new preclinical study reports that the Astragalus compound astragaloside IV reduces hepatic fat accumulation in mice and human liver ...

Iron Overload, Ferroptosis and the Liver: Mapping a Deadly Network

A new review maps how disrupted iron homeostasis and ferroptosis drive liver disease, from hereditary hemochromatosis to hepatocellular carcinoma, and ...

TyG index boosts simple MASLD screening model for rural older adults

A cross-sectional study of 3,020 rural Chinese older adults found that a screening model using routine health indicators, with the ...

Cumulative Cholesterol-HDL-Glucose Index Predicts Cardiometabolic Multimorbidity in MASLD

A nationwide Chinese cohort study links higher cumulative CHG index exposure and persistently high change patterns to increased risk of ...

Liver Biopsy Becomes a Precision Tool in the Age of Non-Invasive Testing

A narrative review argues that liver biopsy should be reserved for cases of diagnostic uncertainty rather than used routinely, as ...

Pandemic Dietary Shifts Away from Rice Linked to Fatty Liver Risk in Korea

A KNHANES-based analysis found that COVID-19-era shifts away from traditional rice-based dishes toward processed grains, oil-based dishes, and animal foods ...

Can Genes and Gut Microbes Predict Who Responds to Semaglutide for Liver Disease?

A new review builds an evidence-tiered framework for predicting GLP-1 therapy response in fatty liver disease using host genotype and ...

Liver Fibrosis, Not Fatty Liver Alone, Signals Macrovascular Risk in Type 2 Diabetes

An analysis of 2,238 patients with type 2 diabetes from the National Metabolic Management Center database found that liver fibrosis, ...

Liver fat on spectral CT links to coronary plaque danger signs in chest pain patients

A retrospective spectral CT study of 568 patients found that hepatic fat volume fraction was associated with total pericoronary adipose ...

Fatty liver disease leaves early fingerprints in the retina, OCTA review finds

A systematic review of seven OCTA studies finds that patients with metabolic liver disease show consistent thinning of the deep ...

Bayesian Model Ties Liver Follow-Up Intensity to Patient Adherence

A Bayesian decision model suggests MASLD follow-up intensity should be calibrated to patient adherence, with aggressive monitoring favored for lifestyle-modification ...

Fatty liver disease blunts the overnight rise of thyroid-stimulating hormone

A prospective cross-sectional study of hospitalised adults found that the normal overnight rise in thyrotropin was attenuated in patients with ...

Statin-Linked GGPP-Rho-YAP Pathway Identified in Cells Around Liver Tumors

UCLA researchers identified a GGPP-Rho-YAP signaling pathway in hepatic stellate cells around MASLD-related liver tumors that statins suppressed in laboratory ...

Cell Death Protein MLKL Emerges as Unexpected Driver of Obesity-Linked Liver Cancer

University of Oklahoma researchers report that MLKL, a protein best known for its role in necroptotic cell death, promotes obesity-related ...

Genetic and metabolic risks linked to early cirrhosis in adults with MASLD

An analysis of about 2,400 adults with biopsy-confirmed MASLD linked early-onset cirrhosis to genetic susceptibility and type 2 diabetes, while ...

Serum Citramalic Acid Emerges as Key Predictor of Fatty Liver Disease Trajectories