Olanzapine Disrupts Central Lactate Control of Glucose Metabolism in Rats
In a rodent study, the antipsychotic olanzapine completely blocked central lactate from stimulating whole-body glucose metabolism and partially inhibited suppression ...
Tag: Glucose Metabolism
Brain FDG PET Scan Flags Cognitive Decline Risk in Psychiatric Patients
A study of 34 psychiatric patients with confirmed cognitive symptoms found that brain FDG PET identified those at risk of ...
Glycolysis enzymes emerge as central players in Alzheimer’s brain energy failure
A new review argues that dysregulated glycolytic and pyruvate-metabolizing enzymes in specific brain cell types form a central axis linking ...
Deleting sugar-sensing genes turns E. coli into a sharper tumor colonizer
A genome-wide knockout screen in E. coli identified metabolic adaptations, including deletions of nonglucose phosphotransferase systems, that enhance bacterial colonization ...
Parkin’s Metabolic Control Emerges as a Key Route to Tumor Suppression
A new open-access review summarizes evidence that the PARK2-encoded E3 ubiquitin ligase Parkin suppresses tumors by regulating mitochondrial function, redox ...
Olanzapine binds hepatic protein Orm2 in drug-linked liver fat study
A new study identifies the hepatic protein Orm2 as a direct target of olanzapine, linking the drug's binding and suppression ...
Diabetes Surgery Reshapes Gut Microbes in Rats, With SADI-S Edging Out Sleeve Gastrectomy
In diabetic rats, both SADI-S and sleeve gastrectomy lowered glucose measures, but the procedures produced distinct gut microbiota changes linked ...
Which Amino Acids Track With Elevated Fasting Glucose in Chinese Children?
A cross-sectional analysis of 6,960 children and adolescents in four Chinese provinces links higher dietary methionine and threonine shares with ...
Adropin Gene Expression May Signal Diabetes Risk Before Disease Onset
A study of 107 people found that ENHO gene expression was higher in prediabetes and lower in type 2 diabetes, ...
Brain rewires energy metabolism to protect memory in late-stage sleeping sickness
In a bioluminescent mouse model of late-stage Trypanosoma brucei infection, the brain shifts from glucose to fatty acid and lipid ...
Mouse study links endothelial FoxO1 to female vascular resilience
A mouse study found that endothelial FoxO1 supports capillary remodeling, mitochondrial integrity and metabolic health in females while producing opposite ...
Lung cancer rewires its metabolism into a dynamic, adaptive network
A new review argues that lung tumours run an integrated, adaptable metabolic network rather than isolated pathways, explaining growth under ...
PET scans reveal how anorexia nervosa reshapes insulin sensitivity tissue by tissue
A Finnish PET imaging study maps insulin-stimulated glucose uptake across muscle, fat, liver, gut, and brain in women with anorexia ...
Obesity from the perspective of the liver
A new review argues that obesity can be understood as a disorder of hepatic glucose and NADPH handling, in which ...
Aged Versus Fresh White Tea: Decade of Storage Reshapes Anti-Obesity Effects in Mice
A new mouse study shows that ten-year storage transforms white tea chemistry, with aged tea offering stronger liver and lipid ...
Bullfrog brains found to brew their own backup fuel when glucose runs dry
University of Missouri researchers found that bullfrog brains can produce ketone bodies locally when glucose is scarce, a built-in backup ...
How Exercise Reprograms Glucose Metabolism to Fight Osteoporosis
A new review reveals that exercise protects against osteoporosis by reprogramming how bone cells burn glucose, linking glycolysis, lactate signaling, ...
A Fading Mitochondrial Fat May Drive the Way Aging Muscles Change Shape
New research shows that the age-related decline of the mitochondrial lipid cardiolipin causally drives the shift from fast glycolytic to ...
Metabolism Holds the Key to Stronger CAR T Cell Therapies, Review Argues
A Nature Reviews Cancer review argues that metabolism, from CAR design and manufacturing conditions to the patient's diet, is a ...
Brain Waste-Clearance System Scans Could Predict Epilepsy Surgery Success
A new study links the brain's glymphatic waste-clearance function to seizure freedom after temporal lobe epilepsy surgery, revealing divergent glymphatic-metabolic ...
