Washout maps could tell brain tumor regrowth from radiation damage after treatment
A novel MRI washout ratio separated recurrent brain tumor from radiation necrosis with an area under the curve of 0.86, ...
Tag: Glioblastoma
AI-Powered Map of Glioblastoma Reveals Tumor Ecosystem States and Immune Programs
A machine-learning-assisted reanalysis of single-cell and bulk transcriptomic data provides a reproducible framework for characterizing glioblastoma ecosystem states while carefully ...
Brain Scans Miss Hidden Tumor Spread, Landmark Glioma Imaging Trial Reveals
A prospective Canadian pilot study found that FET-PET/MRI revealed significantly larger metabolically active tumor volumes than conventional MRI in more ...
Dual Immunotherapy Clues Reveal How to Wake the Immune System Against Glioblastoma
Two UCLA-led studies identify T-cell infiltration as the key to effective glioblastoma immunotherapy and introduce a preclinical model that recreates ...
Blood Test Clue: Monocyte Recovery During Glioblastoma Treatment Predicts Longer Survival
A new study finds that patients with IDH-wildtype glioblastoma whose circulating monocyte counts are preserved during chemoradiotherapy survive substantially longer, ...
The Methylation Test That Decides Brain Cancer Treatment Faces a Reckoning
A new Mayo Clinic review in the Journal of Neuro-Oncology examines how MGMT promoter methylation guides brain tumor treatment, why ...
Weekly MRI Reveals Radiation’s Early Fingerprint on the Brain’s Memory Hub
Weekly diffusion MRI during six weeks of partial-brain radiation therapy for high-grade glioma reveals a progressive, dose-dependent increase in hippocampal ...
Immunotherapy Added to Standard Treatment Shows Early Promise Against Aggressive Brain Tumors
A retrospective study of 25 patients suggests that adding the anti-PD-1 antibody pucotenlimab to concurrent radiochemotherapy produced tumor responses and ...
Infections After Radiotherapy May Signal Poorer Survival in Glioblastoma Patients
A retrospective cohort study of 152 glioblastoma patients found that culture-positive infections after radiotherapy, predominantly Gram-negative respiratory and urinary infections, ...
Hidden Ubiquitin Switch That Lets Brain Tumors Evade Immune Attack Is Revealed
New research reveals that the ubiquitin ligase BTRC destroys the RNA-binding protein hnRNPC, whose stabilization of PSD4 mRNA boosts PD-L1 ...
AI Learns to Read Every Clue in Brain Cancer Data, Review Finds
A new review in the Journal of Neuro-Oncology finds that machine learning, especially multimodal AI, is transforming brain cancer outcome ...
Bioprinted Blood–Brain–Tumor Barrier Spheroids Put a ROS-Producing Ruthenium Drug to the Test Against Glioblastoma
Researchers built a 3D bioprinted blood–brain–tumor barrier spheroid that self-organizes into barrier and tumor layers and showed that a ROS-producing ...
Tiny Gene Regulators Show Promise Against the Deadliest Childhood Brain Tumors
New research shows that restoring the microRNAs miR-34a and miR-34c suppresses the survival, migration, invasion, and stemness of pediatric grade ...
Why EGFR Drugs Fail in Glioblastoma: A STAT3 Escape Route Takes Center Stage
A new review argues that glioblastoma evades EGFR-targeted therapies through compensatory STAT3 activation, positioning the EGFR–STAT3 axis as an adaptive ...
Famed brain cancer drug turns out to hit a metabolic enzyme, not its intended target
A comprehensive chemical biology study shows that the celebrated KDM4 inhibitor QC6352 and its clinical analog zavondemstat kill glioblastoma stem ...
Brain-Penetrating Acridine Drug JP-1302 Cripples Cancer Cells by Shutting Down Ribosome Factory
A brain-penetrating acridine compound originally developed as an adrenergic receptor antagonist potently shuts down RNA polymerase I transcription, degrades the ...
Two-Pronged Immunotherapy Strategy Cracks Glioblastoma’s Defenses in Preclinical Study
Wistar Institute scientists report that combining the kidney cancer drug axitinib with a 4-1BB agonist overcame myeloid cell suppression and ...
Glioma Diagnosis Goes Molecular, But Most of the World Cannot Afford It
A new review warns that the molecular tests defining modern glioma diagnosis remain out of reach for most of the ...
NIH Pioneer Award Backs Scientist Building Cancer Therapies That Evolve Alongside Tumors
NIH has awarded its Director's Pioneer Award to Sylvester Comprehensive Cancer Center virologist Leor Weinberger for developing an evolving oncolytic ...
Gut Microbes May Shape Glioblastoma Immunity, But Evidence Falls Short of Proof
A new review finds growing preclinical evidence that the gut microbiome can influence glioblastoma immunity, while warning that human evidence ...
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