Three Synaptic Receptors Define Aggressiveness in Glioblastoma
Researchers identified a three-receptor signature involving HRH1, ADRA2B, and CHRM3 that defines glioblastoma aggressiveness and correlates with poor patient survival.
Tag: Glioblastoma
Organoids and assembloids reshape how researchers model glioblastoma
A new review in Medical Oncology examines how organoid and assembloid technologies could overcome the limits of conventional models in ...
Penn Medicine Experts to Address Value and Advances in Radiotherapy
Penn Medicine researchers and clinicians will present clinical-trial research, professional priorities and communication strategies at ASTRO’s 68th Annual Meeting in ...
PTN-Secreting Glioblastoma Subclone Rebuilds the Immune Niche to Seed Distant Recurrence
Single-cell sequencing and mouse experiments show that PTN-positive glioblastoma cells recruit anti-inflammatory macrophages through a PTN-NCL interaction, creating the immune ...
Global tumor board maps investigational options for glioblastoma with MDM2 and EGFR amplifications
A new Oncotarget case report details how the WIN Consortium's international molecular tumor board evaluated investigational EGFR, MDM2, CDK4/6 and ...
AI Maps Glioma Ecosystems and Exposes a Macrophage-Driven Vulnerability in Glioblastoma
An AI-driven single-cell and spatial multi-omics study defines three glioma ecosystem states and shows that a hypoxic myeloid-mesenchymal state independently ...
Bacteria Living Inside Brain Tumors Track How Aggressive Gliomas Are
Sequencing of tumor tissue from 107 glioma patients reveals microbial signatures linked to tumor grade and survival, with predicted metabolic ...
Scheduled Brain Tumor Surgery Keeps Patients Home Longer Without Harming Survival
A single-center retrospective cohort of 166 adults with newly diagnosed high-grade glioma found that scheduled resection patients spent 8.9 more ...
Rare NF1-Linked Brain Tumors Show Partial Shrinkage on MEK Blocker Mirdametinib
A retrospective MD Anderson cohort of nine adults with NF1-associated high-grade glioma found partial radiographic responses in two patients treated ...
Material deprivation linked to fewer days home after glioblastoma diagnosis
An Ontario cohort study linked greater neighborhood material deprivation with 36.2 fewer adjusted days at home during the first year ...
Review frames microbiome–mitochondria crosstalk in glioblastoma research
A review frames microbiome-derived metabolites and mitochondrial activity as a proposed research axis for glioblastoma metabolism and immunity, while noting ...
Lactylation links glioblastoma metabolism to progression and resistance
A 2026 review links lactate-driven protein lactylation to glioblastoma growth, stemness, immune escape and treatment resistance in preclinical models, while ...
Autophagy’s Context-Dependent Roles Shape Solid-Tumor Treatment Strategies
A 2026 collection of five reviews and one small tissue-expression study shows that autophagy can restrain or support solid tumors ...
Stigmasterol suppresses glioblastoma growth through mitochondrial dysfunction and oxidative stress
A plant-derived sterol called stigmasterol sabotages the metabolic machinery of glioblastoma cells by impairing mitochondrial function and increasing oxidative stress, ...
MRI Radiomics Model Predicts IL13Rα2 Expression and Survival in Glioblastoma
Glioblastoma remains one of the most formidable opponents in modern oncology. This aggressive brain tumor, classified by the World Health ...
Sortilin emerges as a two-faced switch driving glioblastoma stemness and drug resistance in 3D spheroids
New research from Montreal reveals that the sorting receptor SORT1 links lipid remodeling, stemness and drug resistance in 3D glioblastoma ...
Glioblastoma Pipeline Shifts to Biomarker-Guided Combination Therapies
A new Oncoscience perspective maps the 2025–2026 glioblastoma clinical trial pipeline across four mechanistic domains, showing how biomarker-guided selection and ...
Hidden cancers inside ovarian teratomas: solid clues that flag rare transformation
A rigorous 15-year single-center review of 385 ovarian mature teratomas reveals that somatic neoplasms arise in 3.1 percent of cases, ...
Supportive Care Clinic Offers Lifeline for High-Grade Glioma Patients
A retrospective study found that a dedicated best supportive care clinic achieved high appointment uptake and generated 29 CNS-led interventions ...
Microglia-Mimicking Nanoparticles Deliver CO and GSDME to Fire Up Glioblastoma Immunotherapy
A biomimetic nanoplatform cloaked in microglial cell membranes delivers carbon monoxide, manganese ions, and Gasdermin E across the blood-brain barrier ...
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