HAT1 Emerges as a Driver of Glioblastoma Growth and Drug Sensitivity
A multi-omics study identifies the epigenetic regulator HAT1 as upregulated in glioblastoma, where its inhibition slows tumor growth and boosts ...
Tag: Glioblastoma
Meningiomas Dominate a Decade of Brain Surgery in Upper Egypt
A 10-year surgical series from Assiut University Hospital found meningiomas were the most common CNS tumors, with male sex, pediatric ...
Long Noncoding RNA SNHG4 Emerges as a Player Across Multiple Human Cancers
A new review consolidates reported expression patterns, mechanisms, and clinical potential of the long noncoding RNA SNHG4 across six cancer ...
Oxygen-Generating Liposomes Boost Dual Light Therapy Against Hypoxic Glioma Cells in Lab Tests
A microfluidically fabricated liposome co-loaded with a copper phthalocyanine photosensitizer and catalase cut hypoxic C6 glioma cell viability to about ...
Epigenetic switch drives ERK signaling in glioblastoma, study finds
A study identifies an SP1/P300/TRAF3IP3 signaling axis that links promoter-specific chromatin remodeling to persistent ERK activation in glioblastoma.
Glioblastoma silences the brain’s braking system to fuel its own growth
Baylor College of Medicine researchers report in animal models that glioblastoma co-opts inhibitory GABA signaling through GAT-1 and DBI to ...
Proteasome inhibitor primes temozolomide response in a molecular subset of recurrent glioblastoma
An interim analysis of the BORTEM-17 phase IB/II trial found that sequential bortezomib and temozolomide achieved disease control in four ...
Blocking immune cell lipid signals may contain glioblastoma before surgery
VIB-KU Leuven researchers report that blocking lipid signals from brain immune cells made glioblastoma less invasive in mouse models and ...
Ultrasound-Boosted Implant Aims to Push Drugs Deeper Into the Brain
MIT researchers have built an implantable device that pairs a 24-transducer ultrasound array with a drug-delivery cannula to spread therapeutic ...
MicroRNA miR-22-3p drives radiation resistance in glioblastoma by suppressing TET1
A new study finds that the microRNA miR-22-3p promotes glioblastoma radioresistance and downregulates the DNA demethylase TET1, while inhibiting it ...
PCGF1 Drives Glioma Cell Growth by Raising Levels of CCDC34
A study combining database analyses, glioma tissue samples, and cell-line experiments reports that PCGF1 upregulates CCDC34, which is associated with ...
Frontiers Retracts Corrigendum on ABTL0812 in Glioblastoma Over Image Concerns
Frontiers in Oncology has retracted a 2025 corrigendum on the anticancer effects of ABTL0812 in glioblastoma models after the authors ...
Sweeteners and food additives may reshape gut microbes linked to brain cancer
A narrative review proposes that food additives could alter gut microbes in ways relevant to glioblastoma, while stressing that no ...
Experimental Compounds Curb Glioblastoma Cell Invasion in Tissue Slice Models
In ex vivo xenograft tissue slice co-cultures, indole analogs and the aryl sulfonamide AqB011 potently inhibited glioblastoma cell invasion into ...
Long noncoding RNA MANCR drives glioblastoma growth via miR-205-5p and CASP3
A new study finds that the long noncoding RNA MANCR is elevated in glioblastoma and promotes tumor growth and invasion ...
Cancer Stem Cells, Immune Evasion and Vascularization Drive Therapy Resistance in Brain Tumors
A new review in the Journal of Translational Medicine examines how cancer stem cells, vascularization and immune evasion contribute to ...
Three Synaptic Receptors Define Aggressiveness in Glioblastoma
Researchers identified a three-receptor signature involving HRH1, ADRA2B, and CHRM3 that defines glioblastoma aggressiveness and correlates with poor patient survival.
Organoids and assembloids reshape how researchers model glioblastoma
A new review in Medical Oncology examines how organoid and assembloid technologies could overcome the limits of conventional models in ...
Penn Medicine Experts to Address Value and Advances in Radiotherapy
Penn Medicine researchers and clinicians will present clinical-trial research, professional priorities and communication strategies at ASTRO’s 68th Annual Meeting in ...
PTN-Secreting Glioblastoma Subclone Rebuilds the Immune Niche to Seed Distant Recurrence
Single-cell sequencing and mouse experiments show that PTN-positive glioblastoma cells recruit anti-inflammatory macrophages through a PTN-NCL interaction, creating the immune ...
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