Cohesin keeps compact active genome domains from mixing in living cells
Live-cell super-resolution imaging in human cells shows that active euchromatin forms compact dynamic domains and that the cohesin complex prevents ...
Tag: Gene regulation
Wheat’s Hidden Genome: New Framework Aims to Turn Untapped DNA Diversity into Predictive Breeding
A new review proposes the Pan-Genome to Pan-Phenome framework, a conceptual roadmap for translating hidden wheat genomic variation such as ...
AlphaGenome Atlas Predicts Effects of Billions of DNA Changes
AlphaGenome Atlas provides AI-generated predictions for more than 9 billion possible single-letter DNA changes across hundreds of human cell types ...
TWAS sign errors reach 33% in complex-trait analyses
A Nature Genetics analysis estimated that TWAS assigns the wrong effect direction to 23% of plasma-protein associations and 33% of ...
Kallmann family study finds PROK2 upregulation with uncertain ANOS1 variant
A study of two Polish brothers with Kallmann syndrome identified an uncertain-significance ANOS1 variant and concordant PROK2 upregulation in blood, ...
The regulatory role of DzERF94 in carotenoid biosynthesis during ripening in durian (Durio zibethinus) pulp
A four-cultivar durian study links DzERF94 and DzLCYE expression during ripening to lutein accumulation, while tomato assays show that DzERF94 ...
GLIS3 regulates astrocyte differentiation in human stem cells
Experiments in mouse-derived astrocytes and human embryonic stem cells identify GLIS3 as an upstream regulator of astrocyte differentiation and neural ...
Defective HIV proviruses reprogram T cells at selected integration sites
A cellular study shows how transcriptionally active defective HIV proviruses can reprogram CD4 T cells through integration-site-specific effects on host ...
Wheat remembers the cold: Molecular changes prepare plants for the next chill
An experimental study in wheat found that recovery after mild cold exposure involved delayed gene responses and histone-modification changes associated ...
MICA variants may tune microRNA control of immune surveillance
A mini review finds that microRNAs regulate the immune-surveillance protein MICA and proposes that naturally occurring MICA variants may alter ...
sncRNA signatures underlying HIV-1 restriction in elite controllers
A comparative CD4+ T-cell study linked elite control of HIV-1 to reduced miR-99b-5p and miR-125a-5p, whose inhibition modestly reduced viral ...
Flipped DNA segments rewire mosquito chromosomes and malaria immunity genes
A new BMC Biology study shows that chromosomal inversions in Anopheles mosquitoes reshape 3D genome folding and rewire enhancers near ...
Salmonella Response Regulator NarL Found to Control Key DNA Repair Gene
New research shows that the NarL protein binds directly to the promoter of the DNA repair gene ogt in Salmonella ...
Beneficial Bacterium Rewrites Sweet Orange Gene Expression to Fight Anthracnose
Researchers identified the transcription factor CsWRKY40 as a candidate regulator linked to Bacillus subtilis-mediated reduction of anthracnose symptoms in sweet ...
Non-coding RNAs emerge as diagnostic and therapeutic leads in abdominal aortic aneurysm
A new review maps how microRNAs, long non-coding RNAs and circular RNAs regulate the biological processes driving abdominal aortic aneurysm ...
Cancer Cells Selectively Strip Gene-Rich Regions of the Y Chromosome to Fuel Tumor Growth
A new study shows that cancer cells selectively erode gene-rich regions of the Y chromosome, disrupting regulatory pathways and opening ...
Cancer Protein Awakens Silent DNA With Help From a Molecular Partner, Fly Study Shows
A Barcelona team showed in fruit flies that the cancer-linked protein ETV4 activates normally silent GGAA microsatellite DNA only by ...
Gene-Braking Protein Complex Turns Out to Be a Fertility Switch in Plants
New research in Science Advances shows that the DREAM complex, long known as a gene-silencing brake in dividing cells, activates ...
Small RNA Molecule Shows Promise Against Ovarian Cancer Chemoresistance
A new study shows that the microRNA-197-3p molecule, which is depleted in ovarian cancer, directly suppresses the collagen protein COL4A6 ...
Ancient Jumping Genes May Help Wheat Survive Drought Through Epigenetic Control
A new study reveals that DNA methylation and ancient transposable elements may help wheat landraces fine-tune gene expression under drought, ...
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