Goat gene study maps DNA switches behind muscle growth and body size
Researchers mapped the promoter and enhancer regions of the goat ADAMTS15 gene, found its expression peaks in embryonic muscle, and ...
Tag: Gene regulation
New Algorithm Tidies the Chaos of Genomic Motif Data
Every cell in the human body contains the same genome, yet a skin cell, a neuron, and an immune cell ...
Cells May Glow With Purpose: Biophotons Proposed as a Hidden Language Between Mitochondria and DNA
A new hypothesis paper proposes that ultra-weak photons emitted by mitochondria are absorbed and re-emitted by nuclear chromatin, forming a ...
Master Switch PRDM1 Steers Natural Killer Cell Maturation and Cancer Defense
A new review details how the transcriptional repressor PRDM1 orchestrates natural killer cell maturation, effector function, and tumor suppression, with ...
RNA Molecules Found to Drive Aggressive Leukemia Through Oncocondensates
Vienna researchers developed the bicon-seq method and discovered that the long non-coding RNA Gas5 is a functional component of leukemia-driving ...
Genetic Deletion Rewrites the Rules of Methylation Inheritance in Plants
The discovery that VIM2 and VIM4 act as dosage-sensitive negative regulators of CG methylation maintenance forces a reconsideration of how ...
Apple gene switch discovered that keeps tree branches in check
Researchers in China have identified the MADS-box transcription factor MdAGL29 as a negative regulator of shoot branching in apple, showing ...
Massive Cell-by-Cell Map Reveals the Cerebellum’s Hidden Role in Alzheimer’s Disease
A single-nucleus multiome atlas of over 100,000 brain cells reveals disease-linked regulatory programs and potentially causal genetic variants in the ...
AI Tool PeTMiner Uncovers Hidden RNA Regulators That Shape Plant Gene Expression
Researchers have developed PeTMiner, a deep learning framework that uses a plant RNA foundation model, hierarchical attention, and adaptive loss ...
Human knees pay an evolutionary price for walking upright, study finds
Israeli and Japanese researchers report in Nature that reduced cartilage cushioning molecules, an evolutionary trade-off tied to human traits, explain ...
Hidden DNA Repeats Point to a New Alzheimer’s Risk Gene, Long-Read Study Reveals
A hybrid long-read and short-read sequencing study has identified a common CCG repeat in the FAM193B promoter as a genome-wide ...
Ancient Jumping Genes Turn Out to Be Hidden Architects of the Human Cortex
A Nature Neuroscience commentary highlights new evidence that genetic variants within Alu transposable elements help shape the size and structure ...
Yeast Cell Model Shows Cell Geometry Reshapes Gene Network Predictions
A spatially resolved model of the yeast galactose switch shows that intracellular architecture, especially ER-bound translation, changes gene regulation predictions.
Why Some Neurons Survive: Identity Maintenance May Set the Threshold of Neurodegeneration
A new PLOS Biology essay proposes that a neuron's capacity to maintain its subtype-defining gene-regulatory machinery may set the stress ...
New Tool HiFIseek Hunts Hidden Cancer Mutations in the Genome’s Dark Regulatory Regions
A new computational pipeline called HiFIseek systematically links damaging non-coding mutations to cancer genes, revealing that regulatory regions of drivers ...
Ancient DNA Reorganization May Explain How Octopuses Grew Such Complex Brains
A University of Vienna study finds that an ancient burst of genome reorganization created 3D DNA interactions, or regulatory entanglement, ...
One Master Switch: How a Soil Bacterium Coordinates Warfare and Microbiome Reshaping
A new study reveals that the regulatory protein GacS acts as a master switch in Pseudomonas fluorescens, coordinating antibiotic production ...
One Obesity Gene Variant Rewires Nearly 100 Genes in Fat Cells, Study Finds
Researchers combined single nucleus RNA-sequencing with GWAS and UK Biobank data to show that an obesity-linked variant in SREBF1 allele-specifically ...
CRISPR Screen Maps the Hidden Control Network of the Body’s Pollution-Sensing Receptor
A genome-scale CRISPR screen in human hepatocytes has revealed an extensive network of regulators governing the aryl hydrocarbon receptor, including ...
Massive single-nucleus atlas reveals how genetic risk for brain disease acts cell by cell
A single-nucleus atlas of 5.6 million brain cells from 1,384 donors maps cell-type-specific genetic regulation underlying Alzheimer's disease, schizophrenia and ...
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