Tag: Gene regulation

A new Brain Informatics review traces how AI methods, from co-expression statistics to causal graph neural networks and foundation models, ...

A weighted-voting ensemble called fourSynergy outperformed individual 4C-seq algorithms in leave-one-group-out cross-validation, reaching a mean F1-score of 0.31 and mean ...

A computational reanalysis of public EBV data finds that promoters contacted by the viral EBER noncoding RNAs remain chromatin-accessible yet ...

A new study shows the transcription factors SIX1 and TEAD1 synergistically promote colorectal tumor growth by directly co-regulating the CTGF ...

A genome-wide DAP-seq study in mungbean identifies VrWBC27 and VrLBD27 as likely direct transcriptional targets of the VrMYB80 regulator of ...

A computational survey of 381 oral bacterial genomes found 48,234 G-quadruplex motifs, with a 2.5 to 3-fold enrichment in promoter ...

A genome-wide study of switchgrass identified 79 HIPP genes and found that silencing PvHIPP23 improves cadmium tolerance while reducing root ...

A newly identified mitochondrial long noncoding RNA, lncOriL, found in zebrafish and conserved in humans, may reveal an unrecognized layer ...

A population-scale single-nucleus study of 287 human skeletal muscle biopsies maps cell-type-specific eQTLs and caQTLs that colocalize with thousands of ...

A new study finds that the Alx4 gene shows divergent limb bud expression in chicken and mouse, yet its protein ...

Using native long-read nanopore sequencing, researchers have simultaneously mapped 5mC and 5hmC across the whole genome of human neuronal nuclei, ...

UniLoopNet predicts enhancer–promoter, enhancer–enhancer, CTCF-mediated, and stripe-associated chromatin interactions from DNA sequence using a multi-task deep learning framework.

A study in BMC Medical Genomics finds that miR-183-5p is upregulated in the serum of adolescent idiopathic scoliosis patients, shows ...

A donor-heart study finds that schizophrenia is associated with a cardiomyocyte state in which molecular output is preserved but regulatory ...

University of Basel researchers used single-molecule chromatin tracing in C. elegans embryos to reveal three distinct types of large heterochromatin ...

A newly characterized CaHY5-CaNAC83 regulatory pathway in pepper activates anthocyanin biosynthesis genes, pointing to new tools for purple-pepper breeding.

A multi-dataset bioinformatics analysis prioritized 2,505 candidate Arabidopsis genes associated with links between m6A RNA modification and alternative polyadenylation under ...

A single-cell atlas of 232,251 developing fruit fly neurons links gene activity to regulatory DNA switches and suggests that neuronal ...

Penn State researchers found that cancer-linked BRD4 can bind nucleosomes through both DNA contacts and recognition of modified histones, challenging ...

A new theoretical framework proposes that early adversity alters the developing biological architecture through which later inputs are transformed into ...