Tag: ferroptosis

A focused preclinical review finds that natural products can suppress NRF2-linked antioxidant defenses in hepatocellular carcinoma while protecting non-malignant liver ...

An integrated computational framework combining multicohort transcriptomics, machine learning, molecular dynamics, and single-cell perturbation identifies coumestrol, CD38, and MAPK8 as ...

A new Perspective proposes a unified pharmacological-toxicological framework treating ferroptosis, mitochondrial stress and redox imbalance as one axis governing both ...

A preclinical study reports that ginsenoside RK3 suppressed osteosarcoma growth in cells and mouse xenografts by downregulating PRMT5, promoting GPX4 ...

A new review details how the RNA modification m6A influences cell death, inflammation and risk factors in aortic dissection, pointing ...

Researchers at the University of Cologne have identified a shared metabolic vulnerability in small cell lung cancer, where all cell ...

Human kidney transcriptomics associated ASPHD1 with adaptive proximal-tubule states, while cell experiments found that silencing it increased apoptosis- and ferroptosis-associated ...

Preclinical experiments found that tetrandrine promoted ferroptosis in NSCLC models, enhanced CD8⁺ T-cell effector responses and improved anti-PD-1 tumor suppression ...

SLC5A12 marked an invasive HNSCC state, and experimental knockdown reduced tumor-cell behaviors and xenograft growth in preclinical models.

Sodium selenite reduced ferroptosis and improved bone formation through GPX4 in cell and ovariectomized mouse experiments, preclinical findings that do ...

A CRISPR knockout study in MDA-MB-231 triple-negative breast cancer cells links LCN2 loss to reduced migration, invasion and substrate-dependent adhesion, ...

Cardiomyocyte-specific PIK3R1 deletion improved heart function, mitochondrial balance and ferroptosis-related measures in male mice with diabetic cardiomyopathy, while increased PI3K/Akt/Nrf2 ...

A local genetic screen linked MST1, DLK1, ITIH1 and SAA1 to intervertebral disc-disorder outcomes, while single-cell tissue analysis and a ...

A preclinical study finds that tubocapsenolide A inhibits PLK1, disrupting ESCRT-mediated damage clearance and restoring oxaliplatin sensitivity in resistant colorectal ...

A review finds that programmed cell death can promote immune evasion or antitumour immunity in oropharyngeal cancer depending on pathway ...

Astragaloside IV reduces pathological cardiac hypertrophy and suppresses ferroptosis in separate models, but direct experiments are needed to establish whether ...

A new review details how the NRF2 transcription factor shields cancer cells from iron-dependent ferroptotic death and how natural and ...

Chronic kidney disease is a slow-motion catastrophe. Millions of people live with kidneys that are quietly being replaced by scar ...

A seven-day heat stress experiment reveals how farmed golden pompano livers mobilize antioxidant defenses, suppress immunity, and remodel bile acid ...

A new study links tumor hypoxia to ferroptosis suppression via SQOR-mediated coenzyme Q reduction, offering a potential strategy to overcome ...