TBK1 clears aggregation-prone TDP-43 via an IFNβ-immunoproteasome pathway in ALS models
Researchers report that the ALS-linked kinase TBK1 clears aggregation-prone monomeric TDP-43 in neurons by inducing interferon-β and the immunoproteasome, an ...
Tag: ER stress
Blocked protein cleanup reroutes toxic TDP-43 cargo through extracellular vesicles
In motor neuron–like cells, inhibiting the proteasome or autophagy reshapes extracellular vesicle cargo and spreads proteotoxic stress to recipient cells.
Blocking an Inflammatory Signal Protects Corneal Cells from Preservative Damage
In cultured human corneal epithelial cells, blocking IL-6 trans-signaling with sgp130Fc partially protected against benzalkonium chloride-induced inflammation, oxidative imbalance, ER ...
Multi-omics study links autophagy and ER stress to PFOA toxicity in sperm precursor cells
A multi-omics study in GC-1 spermatogonial cells links PFOA exposure to altered autophagy, ER stress signaling and oxidative imbalance, with ...
IL-24 steps out of the shadows as a central regulator of liver disease
A new review in Molecular Biology Reports maps how interleukin-24, once known only as a melanoma differentiation gene, regulates hepatocellular ...
Proteostasis Collapse and Unfolded Protein Response-Mediated Neurodegeneration in Prion Disease
Prion diseases are among the rarest and most uniformly fatal neurodegenerative disorders known to medicine. Conditions such as Creutzfeldt-Jakob disease, ...
Cell’s Cargo Trucks Caught Raising the Alarm When Protein Traffic Jams the ER
New research in C. elegans reveals that ER-to-Golgi transport proteins actively couple excess cargo to the unfolded protein response in ...
How a Cellular Stress Switch Helps Tumours Hide From the Immune System
A new review reveals how the unfolded protein response, a cellular stress-signalling network, helps tumours evade immune detection and could ...
Scientists Discover a Membrane Receptor That Helps Plants Remember Heat Stress
Researchers in Taiwan have identified SRF6, a heat-inducible receptor-like kinase on the plant cell membrane, as a key regulator of ...
Stressed Cells Hold On to Their Color: ER Stress Links Senescence to Stubborn Age Spots
New research shows that chronic IRE1α-mediated endoplasmic reticulum stress simultaneously boosts melanin production and impairs pigment clearance, explaining why solar ...
Peroxynitrite Influences Calcium Flux in Cardiac Injury
Peroxynitrite, a reactive nitrogen species, has emerged as a crucial player in various pathological processes, including cardiac ischemia-reperfusion injury. Recent ...
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