Tag: DNA Methylation

Researchers showed that whole-genome bisulfite sequencing, EM-seq, and the biomodal evoC kit are all feasible for DNA methylation profiling of ...

A Cell & Bioscience study links compartment-specific AKAP12 promoter methylation to opposing epithelial and stromal programs in colorectal cancer and ...

Healthy women carrying pathogenic BRCA1 or BRCA2 variants have significantly fewer hypomethylated, presumably active ribosomal DNA copies in their blood ...

A new review links EBV-driven lymphoproliferative disorders to disrupted DNA methylation and outlines emerging epigenetic treatment strategies.

Nanopore long-read sequencing that simultaneously reads genetic variants and DNA methylation resolved three difficult KMT2B-related dystonia diagnoses, confirming one uncertain ...

A large observational study of former and current smokers found that higher blood omega-3 fatty acids were associated with better ...

A systematic analysis of hundreds of WGBS datasets finds that apparent mitochondrial DNA methylation is driven mainly by technical artifacts, ...

A new review describes how aberrant DNA methylation and premature senescence of fat cell precursors drive adipose tissue dysfunction in ...

New mouse experiments show that losing the tumour suppressor Apc in pituitary stem cells is enough to cause adamantinomatous craniopharyngioma ...

A new review synthesizes evidence that metabolic stress may shape DNA methylation through methyl-donor availability, impaired demethylation, and chromatin changes ...

BET inhibition suppresses STING expression at its promoter and enhancer regions, weakening the immune response triggered by PARP inhibitors.

A new study reports that quantifying immune cells from DNA methylation patterns matches clinical flow cytometry and CBC results within ...

An EWAS in a Singapore-based Asian cohort identified three novel DNA methylation markers for carotid intima-media thickness and linked one ...

A six-year epigenome-wide association study in older adults without type 2 diabetes found that higher vitamin B12 intake was associated ...

A new review in Clinical Epigenetics distinguishes epigenetic changes proven to persist after glycemic normalization in diabetic cardiomyopathy from those ...

A new review in Epigenetics & Chromatin argues that incomplete epigenetic reprogramming remains the main barrier to efficient mammalian cloning ...

A bioinformatic drug-repurposing study points to the epigenetic regulator DNMT3A in synovial cells as a candidate driver of osteoarthritis inflammation, ...

A 55-CpG DNA methylation signature developed from bone marrow samples and validated in an independent cohort appears to predict AML ...

Structure-guided screening has yielded two compounds that selectively interfere with CDCA7 binding to hemi-methylated DNA, partially recapitulating phenotypes of CDCA7 ...

A bacterium isolated from ephemeral microbial mats at Antarctica's Don Juan Pond survived three months in 3.0 molar calcium chloride ...