Tag: Cellular Senescence

A new review maps how metabolite-driven protein modifications such as lactylation, O-GlcNAcylation and succinylation may link the disc's harsh metabolic ...

A new perspective examines a recent study reporting that telomeres in mouse tails and leukocytes do not shorten with age, ...

A new review in Discover Aging examines how the AP2A1 protein, long known for its role in clathrin-mediated endocytosis, has ...

A randomized placebo-controlled trial of 105 older patients found that liraglutide shortened diabetic foot ulcer healing time and reduced circulating ...

A new review argues that the aging extracellular matrix actively reprograms vascular cells, driving endothelial dysfunction, senescence and arterial stiffening.

An international team has built an atlas of vascular aging, the Human Aging Endothelial Cell Atlas, by analyzing gene activity ...

A new Transplant International special issue shows that older donors and older recipients can achieve strong transplant outcomes when cold ...

A proposed four-criteria framework for selecting senescence-associated antigens finds that neither uPAR nor GPNMB currently meets all requirements.

Laboratory experiments with human tonsil-derived fibroblasts show that senescent lymphoid stromal cells suppress B cell proliferation through contact-dependent mechanisms despite ...

A rat study finds that chronic high-fat diet feeding leaves liver organoid-forming regenerative cells locked in a senescence-like state with ...

A new commentary endorses an engineered human fibroblast-derived extracellular matrix that outperforms recombinant collagen in wound healing, while warning that ...

The 17th International Conference on Skin Ageing & Challenges 2026 in Málaga will examine the biological mechanisms of skin ageing, ...

A peer-reviewed literature review proposes that age-related changes in the brain microenvironment may interact bidirectionally with tumors, influencing progression, treatment ...

A literature review finds stronger experimental support for cellular senescence as a cause of age-related decline than for somatic DNA ...

A literature review links age-related DNA leakage and persistent cGAS–STING signaling to chronic brain inflammation across several neurological disorders.

MIT researchers combined Raman microscopy with spatial RNA sequencing to identify molecular barcodes for senescent cells in skin and lung ...

A peer-reviewed review proposes that chronic DNA damage response signaling may connect senescence, inflammation and other aging processes, while emphasizing ...

A study links RUNX2 mutations in cleidocranial dysplasia to delayed tooth eruption through suppressed dental follicle cell senescence regulated by ...

A small-molecule inhibitor of the asparagine-cleaving enzyme AEP was associated with longer survival, reduced frailty, better cognition, and improved metabolic ...

A laboratory study of primary human lung fibroblasts finds that senescent fibrotic cells from idiopathic pulmonary fibrosis lungs activate antiviral ...