Tag: Cellular Senescence

Inhibiting SERPINE1 suppresses cGAS-STING-driven fibroblast senescence and relieves intestinal inflammation in experimental models of Crohn’s disease.

A narrative review synthesizes evidence showing mitochondrial dysfunction amplifies senescence-associated secretory signaling through context-dependent innate immune sensing rather than serving ...

Researchers combining transcriptomic and proteomic analyses of aging mouse retinas have identified STAT1 as a central regulator driving oxidative stress-induced ...

Researchers established an accelerated aging rat model using D-galactose to elucidate how oxidative stress, mitochondrial impairment, cell cycle arrest, and ...

A preclinical study shows that pentagalloylglucose inhibits ovarian cancer cell growth and promotes senescence by targeting AKT2 for degradation.

A theoretical hypothesis model proposes that asymmetric crosstalk between iron-retaining senescent cells and ferroptosis-susceptible trophoblasts drives divergent placental outcomes in ...

Researchers found that taurine supplementation extended running endurance in senescence-accelerated mice and restored myotube differentiation in aging cellular models.

Researchers using single-cell and spatial genomics have mapped cardiac inflammaging in mice, discovering that age-related inflammation and fibrosis concentrate primarily ...

Researchers discover that tailoring hydrogel stiffness to specific native tissues suppresses cellular senescence through integrin alpha-1 and YAP signaling pathways.

Researchers found elevated cellular senescence markers in schizophrenia and depression, with localized structural brain associations identified in schizophrenia.

A review published in Med-X highlights advanced nanotechnology and cell-based delivery platforms designed to overcome the specificity and toxicity limitations ...

A review in Aging Cell details how histone modifications link aging, metabolism, and neuroinflammation in Alzheimer's disease, proposing a framework ...

A review in Aging Cell proposes that senescent mesenchymal stromal cells drive stem cell aging by dysregulating chemokine synthesis, disrupting ...

A scientific review outlines how extracellular vesicles mediate intercellular communication and carry overlapping molecular signals in aging tissues and cancer.

A newly designed cell-penetrating peptide disrupts the USP25–SIRT1 interaction, raising SIRT1 deacetylase activity and reducing senescence markers in mouse and ...

Researchers kept human fibroblasts in a non-dividing state for six months and found that epigenetic and transcriptomic aging clocks accelerated ...

A study of more than 53,000 participants and experimental animal models found that elevated circulating ANGPTL4 predicts chronic kidney disease ...

A multi-stage study reveals that resistant hypertension is linked to cellular senescence and vascular stiffening driven by dysregulated PTEN and ...

A comprehensive multi-tissue study demonstrates that the tree shrew replicates human cellular senescence, frailty, and transcriptomic aging while responding robustly ...

A study reveals that impaired autophagy driven by elevated branched-chain amino acids accelerates decidual stromal cell senescence and triggers spontaneous ...