Tag: Cellular Senescence

An integrated single-cell atlas of more than 375,000 endothelial cells from 12 human tissues identifies conserved transcriptional hallmarks of vascular ...

An in-vitro study found that resveratrol glucoside reduced senescence-associated cellular changes by altering mitochondrial metabolism and chromatin regulation while showing ...

A mouse study found that endothelial FoxO1 supports capillary remodeling, mitochondrial integrity and metabolic health in females while producing opposite ...

A 2026 perspective synthesizes human, animal and molecular evidence linking cellular senescence, oxidative stress, mechanical loading and microbiome changes to ...

Deep inside nearly every cell, a molecular cleanup crew works around the clock to keep the interior tidy. One of ...

Researchers at Amsterdam UMC report that disrupting the lysosomal enzyme PLA2G15 reduces stress-induced senescence and reshapes BMP phospholipid metabolism in ...

Researchers identified casticin as the key active component of Sanse Powder's transdermal release medium and showed it reduces synovial senescence ...

A new review proposes that the DNA damage response drives PD-L1 upregulation in senescent cells, enabling immune evasion and creating ...

A long-term rat study introduces two composite indices that track liver regenerative potential during accelerated aging and suggest melatonin may ...

A new review argues that the longevity enzyme sirtuin 1 sits at the molecular crossroads between cellular senescence and heart ...

Harvard-led researchers developed a transcriptomic aging clock to screen rejuvenation genes and found that over-expressing the RNA splicing factor SRSF1 ...

A proteomic study of ovaries from 28 women shows the postmenopausal ovary remains biologically active for decades, with mounting inflammation, ...

A new review in Biogerontology argues that the Hippo–YAP/TAZ signalling pathway acts as a central hub linking brain ageing, neurodegeneration, ...

An NYU Abu Dhabi study in EMBO Reports shows that a single cancer-causing gene drives liver cells into distinct senescent ...

A gut bacteria-derived bile acid called hyodeoxycholic acid restores aging bone marrow stem cells and reverses bone loss in a ...

A new review in the Chinese Medical Journal details how extracellular vesicles spread cellular senescence across chronic lung diseases and ...

New research shows that senescent cancer-associated fibroblasts in high-grade serous ovarian cancer secrete Tenascin-C, which activates SDC4-ERK signaling in tumor ...

A new study in Advanced Science shows that losing the glycolytic enzyme TPI1 causes DHAP to accumulate and activates a ...

A new GeroScience review details how failing mitochondria act as both initiators and amplifiers of cellular senescence and the chronic ...

Researchers have discovered Δ246p53, a conserved 18-kilodalton p53 isoform translated from codon 246 that responds to DNA damage and enhances ...