Tag: Cellular Senescence

A new bioinformatic study in Reproductive Sciences shows that a risk model built from telomere-related senescence genes can independently predict ...

A new Nature Communications study reveals that pulsed electromagnetic fields protect stressed skeletons by activating a brain-independent sensory nerve circuit ...

New research in Nature Aging shows that the age-related decline of chaperone-mediated autophagy distorts the senescent cell secretome and disables ...

NIH researchers argue that dementia may be the late-life manifestation of a systemic failure of energy regulation rather than a ...

University at Buffalo researchers found that inhibiting the glutamine-metabolizing enzyme GLS1 with the drug CB-839 reduced urea buildup, restored mitochondrial ...

New research shows that the metabolic protein ANGPTL8 drives the aging of hematopoietic stem and progenitor cells by binding the ...

New research in Aging Cell shows that age-related gut microbiota dysbiosis reduces acetate production and weakens antiviral defense in the ...

A nine-month study in mice shows that chronic senolytic treatment and aerobic exercise each reduce senescent cell markers in the ...

A new study shows that 5-alpha-reductase inhibitor therapy can trigger macrophage pyroptosis, HMGB1–AGER-driven epithelial senescence and club-cell reprogramming in the ...

A phase-2 randomized trial shows intermittent dasatinib plus quercetin significantly improved liver fibrosis and resolved MASH in nearly half of ...

A new mouse study shows that senolytic drugs targeting senescent cells can partially mitigate the bone loss and marrow fat ...

Researchers in India have launched AgingHallmarksDB, an interactive platform integrating 3,111 aging-associated genes across the eleven hallmarks of aging with ...

Researchers engineered two fisetin-derived flavonoid analogs that kill senescent cells up to 27 times more potently than fisetin and reduce ...

A preclinical study finds that spatially fractionated mini-GRID radiotherapy preserves the growth-inhibitory effect of radiation in glioma cells while markedly ...

A prospective cohort study of 7,614 Chinese adults links frequent and severe infection trajectories to accelerated biological aging and higher ...

Researchers have identified a LAPTM5-WWP2-OPTN mitophagy cascade that drives retinal pigment epithelium senescence and subretinal fibrosis through cGAS-STING activation, with ...

A new letter in the Journal of Translational Medicine argues that a senolytic vaccine study showed real therapeutic benefit in ...

New research shows that chronic IRE1α-mediated endoplasmic reticulum stress simultaneously boosts melanin production and impairs pigment clearance, explaining why solar ...

The relentless pursuit of extending human lifespan has fascinated scientists, ethicists, and the public alike, sparking extensive research into the ...

A groundbreaking study published in the Journal of Translational Medicine sheds new light on a critical mechanism involved in age-related ...