Tag: cancer metabolism

A new study shows that both inhibiting and activating the metabolic enzyme PKM2 reduces nuclear accumulation of the protein, lowers ...

A new study reports that MDM4 promotes glycolysis and proliferation in TP53-mutant oral squamous cell carcinoma by stabilizing the enzyme ...

Preclinical experiments show that depriving ovarian cancer cells of cyst(e)ine, or blocking its metabolism with drugs, enhances their responsiveness to ...

A new review summarizes how the amino acid transporter SLC7A5 drives tumor metabolic reprogramming and where targeted therapies against it ...

A new study reports that the cytokine IL-17A drives malignant T-cell proliferation in cutaneous T-cell lymphoma by increasing mitochondrial electron ...

In vivo isotope tracing in KRAS-driven lung cancer mouse models shows that tumor fat synthesis draws mainly on lactate and ...

A combination of low-dose metformin and valproic acid reprograms the metabolism of drug-tolerant persister cells in gastric and liver cancer ...

A new open-access review summarizes evidence that the PARK2-encoded E3 ubiquitin ligase Parkin suppresses tumors by regulating mitochondrial function, redox ...

A new study reports that elevated ACOT7 promotes malignant phenotypes in head and neck squamous cell carcinoma by raising arachidonic ...

A prospective metabolomic study of 35 patients with solid tumors found that ascites fluid shows distinct metabolic profiles depending on ...

A new Frontiers in Oncology Research Topic gathers six articles examining how metabolism, inflammation, immunity and the gut microbiome influence ...

A new study reports that SIRT1-mediated delactylation of NSUN2 suppresses m5C-dependent asparagine biosynthesis in hypopharyngeal squamous cell carcinoma, and that ...

A new study shows that TGF-β-driven PFKM downregulation reroutes glucose toward glycogen storage and promotes invasive, mesenchymal-like behavior in lung ...

RNA modification networks and metabolic reprogramming establish reciprocal circuits that drive hepatocellular carcinoma progression and therapeutic resistance.

A systematic study of 54 cancer cell lines reveals a tissue-linked tradeoff between using glutamine or aspartate for glutamate synthesis, ...

An observational proteogenomic study of 112 pediatric and young-adult high-grade glioma tumors found age- and sex-associated molecular differences and four ...

A cell and patient-cohort study links hypoxia-induced GP73 to HIF-1α-dependent glycolysis, growth, invasion and markers of transarterial chemoembolization resistance in ...

A 346-publication analysis finds rapidly expanding research on SGLT2 inhibitors across cancer safety, antitumor mechanisms, real-world outcomes and cardio-oncology, but ...

A 2026 review links disrupted circadian clock genes with altered cancer metabolism, cell survival, and pathways implicated in tumor progression.

A synthetic enzyme produced pyruvate inside cancer-cell mitochondria, increased oxidative metabolism, altered growth-related gene expression and slowed human melanoma xenografts ...