Tag: cancer metabolism

Targeting cholesterol biosynthesis with statins overcomes resistance to HIF-2α inhibition in colorectal cancer models by triggering ferroptotic cell death.

A review published in Frontiers in Molecular Biosciences examines how structural defects in mitochondria and reactive oxygen signaling drive adaptive ...

Inhibiting the enzyme SHMT2 reduces renal cell carcinoma proliferation and sensitizes cells to the drug sorafenib, suggesting a new therapeutic ...

A new computational workflow identifies TPI1 as a metabolic target in ovarian cancer, with experimental validation confirming its role in ...

A new study in Cancer & Metabolism demonstrates that combining untargeted metabolomics with machine learning can identify distinct metabolic signatures ...

Hepatocellular carcinoma represents a widespread and aggressive malignancy characterized by poor prognosis, where the emergence of therapeutic resistance continues to ...

New flow cytometry protocols enable robust measurement of mitophagy rates and mitochondrial mass in leukemia cells, revealing higher clearance in ...

Researchers have discovered that the transcription factor POU2F1 promotes endometrial cancer progression by directly activating the metabolic enzymes DHCR24 and ...

Researchers discovered that glucose deprivation disrupts the malate-aspartate shuttle by depleting cellular NADH, causing lung cells to synthesize and export ...

Researchers discover that inhibiting the splicing regulator SRRM1 activates ferroptosis to overcome gemcitabine resistance in pancreatic cancer models.

Researchers conducted an in vivo CRISPR screen to identify metabolic dependencies and pathways tied to anti-PD1 resistance in oncogenic Kras-driven ...

A review in Molecular Cancer examines how lactate and lysine lactylation regulate tumor biology, highlight challenges in establishing causality, and ...

Researchers have revealed that the glycolytic enzyme PFKFB4 accelerates hepatocellular carcinoma growth by stimulating lactate-driven histone lactylation to polarize tumor-associated ...

The Ludwig Institute for Cancer Research and Keystone Symposia have announced a joint meeting on tumor and host metabolism to ...

A review in Cellular Oncology synthesizes evidence showing that uridine phosphorylase 1 regulates metabolism, oncogenic signaling, and immune suppression in ...

A study in Cancer & Metabolism reveals that SENP1 drives de novo cholesterol synthesis in prostate cancer by deSUMOylating SREBP2, ...

A new study reveals that fumarate accumulation in kidney cancer cells impairs DNA repair by modifying the RPA1 protein, leading ...

Researchers have identified the antifungal drug butoconazole as a dual inhibitor of energy metabolism that suppresses liver cancer growth in ...

A study reveals that HDAC11 deficiency promotes histone lactylation and metabolic reprogramming to drive pazopanib resistance in renal cell carcinoma ...

A comprehensive review synthesizes decades of clinical trials and mechanistic research to demonstrate that hyperbaric oxygen therapy does not accelerate ...