Breast Cancer Subtypes and Metastasis Timing: An Analysis of German Cancer Registry Data (2000–2024)
An analysis of 172,512 German breast cancer cases shows that molecular subtypes are associated with both the timing and organ ...
Tag: Breast Cancer
MRI Radiomics and Vascular Gene Profiles Capture Different Sides of Breast Cancer Tumor Blood Vessels
A study of 932 breast cancer patients finds that DCE-MRI radiomic subgroups and vascular gene-expression subgroups capture complementary, non-overlapping dimensions ...
Phase 2 Trial Tests Culmerciclib Plus Endocrine Therapy in Advanced Breast Cancer
In a single-arm phase 2 trial of 39 women with HR+/HER2- advanced breast cancer, first-line oral culmerciclib plus an aromatase ...
Body Composition Correlates With Tumor Metabolism in Newly Diagnosed Breast Cancer
A cross-sectional study of 166 newly diagnosed breast cancer patients found that higher adiposity and low muscle mass correlated with ...
Symptomatic breast cancer carries 44% higher recurrence risk in 30-year study of 38,050 patients
A 30-year single-center study of 38,050 Korean breast cancer patients found that symptomatic presentation independently predicted a 44% higher recurrence ...
Chemotherapy-Induced Senescence in Breast Cancer Cells Is Driven by Histone Lactylation
A multi-omics study shows that lactate produced by senescent breast cancer cells drives the SASP through histone H3 lactylation at ...
Natural Compounds Show Promise Against Breast Cancer Stem Cells
A new review examines how plant-derived compounds such as polyphenols, flavonoids, alkaloids and isothiocyanates may target the breast cancer stem ...
Brain metastases rare but deadly as first sign of breast cancer return
An analysis of 5,318 early breast cancer patients found that 2 percent developed brain metastases at first recurrence, with triple-negative ...
Tumor-Made Androgen Marks Breast Cancer Subtype and Survival Odds
Breast tumors with high intratumoral androstenedione show gene activity linked to lower proliferation, earlier stage and better survival, while low ...
Computer screen sifts animal peptides for breast cancer drug leads
A computational pipeline filtered about 1,500 animal-derived antimicrobial peptides down to three candidates that dock strongly against the breast cancer ...
Dual-Drug Liposomes With YIGSR Peptide Target Breast Tumor Cells in Mice
A YIGSR-modified liposome co-loaded with doxorubicin and 5F showed stronger cytotoxicity, higher cellular uptake and greater tumor accumulation than non-targeted ...
Dietary Acid Load Shows No Significant Link to Breast Cancer Risk in Iranian Case-Control Study
A hospital-based case-control study of 155 Iranian women found no significant association between dietary acid load and breast cancer risk, ...
Mycotoxins Show Estrogenic and Cytotoxic Effects in Breast Cancer Cell Lines
A systematic review of 41 in vitro studies finds that zearalenone and alpha-zearalenol act as potent estrogen agonists in ER-positive ...
Methylated ultra-short cfDNA fragments flag breast cancer with perfect test accuracy
A cfMeDIP-seq machine-learning model combining methylation and methylated fragment features distinguished 25 breast cancer patients from 110 healthy controls with ...
First-in-human trial shows B7-H4 antibody-drug conjugate shrinks ovarian, endometrial and breast tumors
A first-in-human Phase 1/2a trial of the B7-H4-targeting antibody-drug conjugate puxitatug samrotecan reported partial responses in heavily pretreated ovarian, endometrial ...
CAR-NK Cells Engineered to Intercept Breast Cancer Metastasis
A new review in Breast Cancer Research outlines a framework for engineering CAR-NK cells to intercept circulating tumor cells, target ...
Breast Cancer Chemotherapy Stiffens the Aorta Fastest in Women Without Hypertension
A CMR study of 97 women with breast cancer found that aortic distensibility fell within three months of starting potentially ...
Research report: Omega-3 fatty acids in aromatase inhibitor-associated dyslipidemia: mechanisms, clinical evidence, and future perspectives
A new review finds a strong biological rationale for omega-3 fatty acids in aromatase inhibitor-associated dyslipidemia but says clinical evidence ...
Machine Learning Maps Three Fatigue Subgroups in Breast Cancer Patients
A cross-sectional study of 1,005 breast cancer patients identified three fatigue subgroups and found perceived stress, depression, and self-compassion were ...
Blood markers shift with chemotherapy in Ghanaian breast cancer patients
A cross-sectional study of 120 Ghanaian participants found that chemotherapy-experienced breast cancer patients showed significantly lower red blood cell, haemoglobin, ...
