Obesity-linked leptin drives DNA hypomethylation in breast epithelial cells
A new study links obesity-associated leptin levels to global DNA hypomethylation and altered EMT gene expression in breast epithelial cells, ...
Tag: Breast Cancer
Astaxanthin Shows Anti-Cancer Activity in Breast Cancer Models, Review Finds
A narrative review consolidates preclinical evidence that the carotenoid astaxanthin inhibits breast cancer cell proliferation, metastasis and angiogenesis, while stressing ...
Tumor-Infiltrating Lymphocytes and Microvessel Density Together Predict Breast Cancer Prognosis
A study of 471 breast cancer patients found that a combined model of tumor-infiltrating lymphocytes-score and microvessel density-score exhibited better ...
Breastfeeding Tied to Lower Breast Cancer Odds in Ethiopian Meta-Analysis
A meta-analysis of eight Ethiopian case-control studies found breastfeeding associated with lower breast cancer odds, while abortion history and oral ...
Extrachromosomal DNA Emerges as Possible Breast Cancer Liquid Biopsy Marker
A new review finds plasma extrachromosomal DNA may complement cell-free and circulating tumor DNA measures in breast cancer liquid biopsy, ...
Delaying Sentinel Node Biopsy After Mastectomy Feasible for DCIS, Trial Shows
A prospective trial found that marking sentinel lymph nodes during mastectomy allowed surgeons to safely postpone biopsy until invasive cancer ...
PET scans before chemotherapy may predict response in breast cancer patients
A retrospective study of 137 patients found that low pretreatment breast TLG and low axillary MTV on PET/CT independently predicted ...
Breast Size Measurements on Planning Scans Predict Radiation Dose to Heart and Lung
A retrospective study of 33 right-sided breast cancer patients links simple target volume measurements on planning CT scans to higher ...
Machine learning models predict severe chemotherapy-induced neutropenia in breast cancer using only pre-treatment data
Machine learning models built only from pre-chemotherapy data predicted severe neutropenia in breast cancer patients with AUCs around 0.75 across ...
Active Thermal Imaging Spots Residual Breast Cancer During Surgery in 90 Seconds
A pilot study reports that an infrared heating and imaging system distinguished cancer-free from cancer-positive surgical margins with 93.33% accuracy ...
New Standard Sets Unified Rules for Growing Breast Cancer Organoids
A newly published consensus standard defines unified workflows, validation criteria and drug testing protocols for breast cancer organoids grown from ...
Neutrophils Disable NK Cells to Fuel Breast Cancer Liver Metastasis
A mouse study finds that neutrophils in breast cancer liver metastases suppress NK cell killing by contact-dependent downregulation of Eomes ...
BRCA1/2 Mutation Carriers Show Fewer Active Ribosomal DNA Copies in Blood
Healthy women carrying pathogenic BRCA1 or BRCA2 variants have significantly fewer hypomethylated, presumably active ribosomal DNA copies in their blood ...
Pathological Complete Response After Breast Cancer Therapy Linked to Better Survival
A retrospective multicenter study of 3,803 breast cancer patients found that pathological complete response after neoadjuvant therapy was associated with ...
Most BRCA Carriers With Breast Cancer Undergo Ovary Removal Within Two Years
A retrospective single-center study of 148 patients found that two-thirds of women with germline BRCA-mutated breast cancer underwent risk-reducing salpingo-oophorectomy, ...
Public cancer investment linked to better survival at Uganda’s leading cancer centre
A five-year study of 12,438 patients at the Uganda Cancer Institute finds that residence outside Kampala, informal employment, and HIV ...
Tomosynthesis cuts interval breast cancers by a quarter in major screening trial
The TOSYMA trial of nearly 100,000 women found that digital breast tomosynthesis reduced invasive interval breast cancers by 29 percent ...
Oral health problems common during active cancer treatment, survey finds
A survey of 188 cancer patients at Ghent University Hospital found that 46.3% reported worsening oral health since starting treatment, ...
High blood sugar reprograms T cells to fight tumors in mouse study
A mouse study in The Journal of Immunology reports that hyperglycemia reprograms T cells through an IGF1-IGF1R signaling pathway to ...
Kitchen Compounds That Rewire the Breast Cancer Tumor Microenvironment
A new review compiles evidence that curcumin, green tea polyphenols, quercetin, and related food-derived compounds can remodel the breast cancer ...
