Unbiased multi-omics comparative profiling of rat synucleinopathy models reveals divergent molecular mechanisms, providing a translational guide for Parkinson's disease drug ...
Researchers at Genentech have demonstrated that direct injection of human alpha-synuclein pre-formed fibrils into the substantia nigra of transgenic mice ...
A review in npj Parkinson's Disease examines the brain lymphatic drainage system's role in Parkinson's disease pathogenesis.
A computational study of Annona muricata fruit phytochemicals identifies spathulenol, caryophyllene oxide and bornyl acetate as the strongest predicted binders ...
A new review details how engineered alpha-synuclein mouse models with defined biochemical defects are transforming Parkinson's disease therapy development.
In a mouse model of early Lewy body dementia, cortical alpha-synuclein pathology reduced individual neuronal activity and altered local circuits ...
A review reveals how microglia and astrocytes act as metabolic checkpoints, dictating whether Parkinson's disease alpha-synuclein aggregates are degraded or ...
A new review argues that gut dysbiosis, immune hyperactivation and HPA axis disruption link idiopathic Parkinson's disease with the systemic ...
A human stem-cell study shows that static membrane inserts and a flowing microfluidic blood-brain barrier chip give strikingly different answers ...
In a Drosophila model of Parkinson's disease, neuronal overexpression of the polyamine enzyme SAT1 reduced alpha-synuclein protein levels, modified stress-response ...
A new review synthesizes evidence that gut microbial dysbiosis and immune dysregulation may fuel the neuroinflammation and neurodegeneration of Parkinson's ...
A rat study finds that eight weeks of daily D-serine at 200 mg/kg produces kidney inflammatory infiltrates and biological alterations, ...
A published protocol details the first randomised, placebo-controlled trial testing whether the oral drug PXS-4728A reduces PET-measured brain neuroinflammation in ...
In an MPTP mouse model of Parkinson's disease, males developed stronger depressive- and anxiety-like behaviors alongside greater nigrostriatal degeneration, hippocampal ...
A new cell study reports that montelukast, a common asthma medication, protected human neuroblastoma cells from rotenone-induced toxicity by modulating ...
In a mouse model of multiple system atrophy, oligodendroglial alpha-synuclein drives early ventral midbrain transcriptional changes in mitochondrial, metabolic and ...
A scoping review finds only four in vivo studies of retinal spectral imaging and spectroscopy in Parkinson disease, with weak ...
A selective, brain-penetrant CD38 inhibitor raised NAD+ levels in rodent brain, protected dopaminergic neurons from alpha-synuclein toxicity in vitro, and ...
A skin-based seed amplification assay detected alpha-synuclein seeds in a 126-participant cohort with 100% specificity and matched cerebrospinal fluid seed-type ...
A pilot observational study detected alpha-synuclein seeding activity in 35.7% of people with persistent olfactory dysfunction after SARS-CoV-2 infection, compared ...
