Loop CAR-T Cells Target Heterogeneous Leukemia Antigens
New loop-structured CAR-T cells targeting CD38 and CD123 show enhanced activity against heterogeneous acute myeloid leukemia in preclinical models.
Tag: acute myeloid leukemia
RIFTT Pipeline Reduces Fusion Gene False Positives in Tumor Data
A new pipeline called RIFTT integrates two fusion callers and novel scoring metrics to reduce false positives in tumor transcriptome ...
Machine learning sharpens leukemia diagnosis but waits on rigorous validation
A literature review finds that machine learning and bioinformatics have improved AML classification and risk stratification, but clinical implementation remains ...
Gilteritinib Yields Five-Year Remission in Relapsed Acute Myeloid Leukemia Case
A patient with relapsed FLT3-mutated acute myeloid leukemia achieved a durable complete remission exceeding five years after switching to gilteritinib.
Systematic Review Evaluates LSD1 Inhibitors Across Early Blood Cancer Trials
A systematic review of 13 early-phase clinical trials found that lysine-specific demethylase 1 inhibitors show biological activity and disease-specific signals ...
Platelet-derived microparticles may drive acute myeloid leukemia progression and inspire nanoparticle drug delivery
A new review examines how platelet-derived microparticles may worsen acute myeloid leukemia by transferring molecular cargo to cancer cells, and ...
FLT3 inhibitors reshape acute myeloid leukemia care as trials push beyond current standards
A new review maps how FLT3 inhibitors became standard therapy across newly diagnosed and relapsed AML while trials test triplets, ...
Single-cell study links an eight-gene program to LSC17-high acute myeloid leukemia
An integrative single-cell and bulk transcriptomic analysis identified an eight-gene non-LSC17 companion program associated with LSC17-high acute myeloid leukemia and ...
Push or Block: Both Directions of PKM2 Activity Kill Leukemia Cells
A new study shows that both inhibiting and activating the metabolic enzyme PKM2 reduces nuclear accumulation of the protein, lowers ...
CD84 Levels Predict Venetoclax Response in Acute Myeloid Leukemia
High CD84 expression correlates with venetoclax resistance in AML, and targeting the CD84-SESN2 pathway sensitized leukemia cells to the drug ...
APR-246 boosts venetoclax activity against TP53-mutated AML cells in vitro
A new in vitro study reports that APR-246 enhanced venetoclax's anti-proliferative and pro-apoptotic effects in TP53 R248Q-mutated AML cell lines, ...
Genetic Study Links Iron-Cell Death Genes to Leukemia Risk via Immune Cells
A Mendelian randomization study finds that ferroptosis-related genes influence acute myeloid leukemia risk directly and indirectly through specific immune cell ...
tRF Fragment Drives AML Cell Growth by Suppressing AGGF1, Study Finds
A tRNA-derived RNA fragment elevated in acute myeloid leukemia promotes cell growth and survival by suppressing AGGF1 and is associated ...
MALAT1 Emerges as Central Driver of Leukemia Cell Survival and Drug Resistance
A new review describes how the long non-coding RNA MALAT1 drives leukemia cell survival, proliferation and chemotherapy resistance in acute ...
FDA-Approved Antibody-Drug Conjugates Reshape Blood Cancer Treatment
A new review synthesizes the clinical evidence, toxicity profiles and resistance mechanisms behind six FDA-approved antibody-drug conjugates for blood cancers.
New Algorithm Reconstructs Tumor Cell Family Trees Under a Strict Evolutionary Rule
Researchers have developed Dolphyin, a combinatorial algorithm that infers 1-Dollo phylogenies from single-cell cancer sequencing data and proved that the ...
Cell-hitchhiking nanotherapeutics aim at the marrow niche in AML, but remain investigational
A new review proposes the EV–platelet–NET axis as a framework for AML marrow niche remodeling and examines investigational cell-hitchhiking nanotherapeutics.
Haploidentical transplants show lower relapse risk for MRD-positive AML patients in EBMT registry analysis
A large EBMT registry analysis of 3385 adults with AML in remission and measurable residual disease found that haploidentical transplantation ...
DNA Methylation Score Sharpens Leukemia Risk Prediction in MDS
A 55-CpG DNA methylation signature developed from bone marrow samples and validated in an independent cohort appears to predict AML ...
Scientists Challenge HERV-K102 Findings in Acute Myeloid Leukemia Study
A correspondence in Blood Research raises four methodological concerns about a study linking HERV-K102 envelope deletion to pyroptosis in acute ...
POPULAR NEWS
-
When the Brain and Immune System Fail Together: Scientists Map the Shared Machinery of Neurological Disease
-
Research report: Synthesis, anticancer properties, and biological profiling of synthetic glycan analogs of proscillaridin A
-
Research report: Conditioned medium from Sanhuang Decoction-pretreated MDA-MB-231 cells attenuates endothelial inflammation and barrier dysfunction
-
Novel Linear-Time Metric Accurately Compares Complex Reconciled Gene Trees