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Home NEWS Science News Biology

Sexual behavior may influence gut microbiome

Bioengineer by Bioengineer
April 10, 2019
in Biology
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CU Anschutz researchers say men who have sex with men have unique microbiomes, may impact immune system

AURORA, Colo. (April 10, 2019) – A person’s sexual behavior could affect their microbiome and immune system, potentially elevating their risk of HIV infection, according to a new study from researchers at the University of Colorado Anschutz Medical Campus.

The study was published last week in the journal PLOS Pathogens.

The microbiome, a community of microbes in the gut, play a major role in driving and shaping the human immune system. But recent studies have shown that men who have sex with men (MSM) have very distinct microbiomes compared with men who have sex with women (MSW), regardless of HIV-infection status.

CU Anschutz researchers wanted to know whether this altered microbiome induces T cell activation associated with HIV transmission risk and increased disease severity.

To study this they took stool samples of 35 healthy men – men who had sex with men and men who had sex with women – and transplanted them into mice. The mice who received the MSM stool samples showed increased evidence of activation of CD4+ T cells, which would put them at a higher risk of HIV if they were human.

They also isolated immune cells from the intestines of HIV negative individuals and exposed them to bacteria from MSM and MSW feces. Human gut derived immune cells exposed to MSM fecal bacteria were more likely to be infected by HIV virus in vitro. This was again linked with increased immune activation by these fecal bacteria.

“These results provide evidence for a direct link between microbiome composition and immune activation in HIV-negative and HIV-positive MSM, and a rationale for investigating the gut microbiome as a risk factor for HIV transmission,” said the study’s senior author Brent Palmer, PhD, associate professor of medicine in the Division of Allergy and Clinical Immunology at the CU School of Medicine.

Exactly why the microbiome of men who have sex with men is so distinct remains unknown. Some have theorized that diet may promote inflammation and thereby activate T cells.

“There is a unique microbiome associated with men who have sex with men that drives immune activation in the gut that may also drive higher levels of HIV infection,” Palmer said. “But we still don’t know exactly why this is.”

Yet understanding this microbiome is important, Palmer said, because it could directly affect the immune system of high-risk men and lead to an increased risk of HIV infection.

###

The study co-authors include Sam X. Li, PhD, and Catherine Lozupone, PhD, of the University of Colorado Anschutz Medical Campus.

About the University of Colorado Anschutz Medical Campus

The largest academic health center in the Rocky Mountain region, the University of Colorado Anschutz Medical Campus is a world-class medical destination at the forefront of transformative science, medicine, education, and healthcare. The campus encompasses the University of Colorado health professional schools, numerous centers and institutes, and two nationally ranked hospitals that treat more than 2 million adult and pediatric patients each year. Innovative, interconnected and highly collaborative, together we deliver life-changing treatments, patient care, and professional training, and conduct world-renowned research powered by more than $500 million in research awards.

Media Contact
David Kelly
[email protected]

Tags: AIDS/HIVBacteriologyCell BiologyEpidemiologyInfectious/Emerging DiseasesMedicine/HealthMicrobiologyNutrition/NutrientsPhysiologySexual Behavior
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