• HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Sunday, May 29, 2022
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
    • BIOENGINEERING
    • SCIENCE NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • FORUM
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Chemistry

Role of subnuclear NSrp70 in immunity-studied at Gwangju Institute of Science & Technology

Bioengineer by Bioengineer
July 14, 2021
in Chemistry
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

Scientists report that the alternative-splicing regulator NSrp70 influences immune T cell development

IMAGE

Credit: Gwangju Institute of Science & Technology

T lymphocytes, or T cells, are immune cells with diverse roles in building the body’s immunity. How does one particular cell type fight against a host of different pathogens? The key to this adaptability is in alternative splicing, wherein the cell produces multiple forms of proteins for identifying different types of invading viruses and microbes, as well as destroying cancer cells. So, it is not surprising that finding ways to improve the production of T cells with enhanced pathogen recognition capacity is an actively researched area of modern science.

In 2011, scientists from the Gwangju Institute of Science and Technology (GIST) in Korea discovered a protein called NSrp70, which is abundant in motile T cells. Located in specific regions inside the cell’s nucleus called nuclear speckles, NSrp70, which is short for nuclear speckle-related protein 70, is a gene regulator. Interestingly, nuclear speckles play an important role in protein production by housing mRNA splicing regulators that cut and join pre-messenger RNA fragments to produce the final messenger RNAs based on the proteins that are produced. With this knowledge, the scientists have been speculating about the possible role NSrp70 plays in the alternative splicing involved in T cell maturation and development.

Now, in a new study made available online on 25 May 2021 and published in Volume 49 Issue 10 of the journal Nucleic Acids Research, scientists from GIST led by Professor Chang-Duk Jun report their findings on the role of this protein and its encoding gene within a physiological environment. Explaining their motivation for the research, Prof. Jun says, “Ever since we discovered and presented NSrp70 to the academic world, we have been exploring its functions and mechanisms of action.”

In experiments with mice, the scientists were able to analyze the function of the protein using a technique known as conditional gene knockout, whereby they inactivated the gene coding for NSrp70 and produced cell samples that lacked the protein. By comparing these cell samples with regular cells, they determined the effects caused by the absence of the protein.

They report that NSrp70 is expressed very early in the cell cycle and plays an important role in T cell development. Specifically, the absence of the protein induced uncontrolled cell growth and death in double positive thymocytes that are T cell precursors. This impeded their progression to single positive thymocytes stymying the formation of mature T cells. NSrp70-deficient mice had a noticeably reduced lymphocyte count in peripheral tissues, and, thus, resulted in unchecked tumor growth, further attesting to the role NSrp70 plays in cancer development. Prof. Jun sums up the findings emphatically, “Our study revealed that NSrp70 is an important regulator of T cell proliferation. This finding can help us mass-produce specific T cells for cell therapy or use mass-produced T cells to inhibit the proliferation of cancer cells through gene therapy.”

The world welcomes such critical findings on nuclear speckles and constituent proteins with eager anticipation!

###

Reference

Authors: Chang-Hyun Kim (1,2), Sang-Moo Park (1,2), Sun-jae Lee (1), Young-Dae Kim (1,2), Se-Hwan Jang (1), Seon-Min Woo (3), Taeg-Kyu Kwon (3), Zee-Yong Park (1), Ik-Joo Chung (4), Hye-Ran Kim (1,2) and Chang-Duk Jun (1,2)

Title of original paper: NSrp70 is a lymphocyte-essential splicing factor that controls thymocyte development

Journal: Nucleic Acids Research

DOI: https://doi.org/10.1093/nar/gkab389

Affiliations:

(1) School of Life Sciences, Gwangju Institute of Science and Technology (GIST)

(2) Immune Synapse and Cell Therapy Research Center, Gwangju Institute of Science and Technology (GIST)

(3) Department of Immunology, School of Medicine, Keimyung University

(4) Department of Hematology-Oncology, Immunotherapy Innovation Center, Chonnam National University Medical School

About the Gwangju Institute of Science and Technology (GIST)

The Gwangju Institute of Science and Technology (GIST) is a research-oriented university situated in Gwangju, South Korea. As one of the most prestigious schools in South Korea, GIST was founded in 1993 and aims to create a strong research environment to spur advancements in science and technology and to promote collaboration between foreign and domestic research programs. With the motto, “A Proud Creator of Future Science and Technology,” GIST has consistently received one of the highest university rankings in Korea.

Website: http://www.gist.ac.kr/

About the author

Chang-Duk Jun is a professor of Immune Synapse & Cell therapy Research Lab at the Gwangju Institute of Science and Technology. His team studies the immunological role of T cell microvilli, which are densely packed with T cell antigen receptors (TCRs) that recognize dendritic cell antigens.

Media Contact
Nayeong Lee
[email protected]

Original Source

https://www.gist.ac.kr/en/html/sub06/060208.html?mode=V&no=201214

Related Journal Article

http://dx.doi.org/10.1093/nar/gkab389

Tags: BiochemistryBiologyCell BiologyGenesGeneticsImmunology/Allergies/AsthmaInfectious/Emerging DiseasesMedicine/HealthMolecular Biology
Share12Tweet8Share2ShareShareShare2

Related Posts

Participant wearing an EEG cap and using the odor delivery device

Seeing how odor is processed in the brain

May 28, 2022
ictB samples

No photosynthetic improvement in ictB transformants in field-grown model crop

May 27, 2022

On the way to smart hearing aids

May 27, 2022

Choking local funding prevents terrorism

May 27, 2022
Please login to join discussion

POPULAR NEWS

  • Masks

    Hidden benefit: Facemasks may reduce severity of COVID-19 and pressure on health systems, researchers find

    44 shares
    Share 18 Tweet 11
  • Breakthrough in estimating fossil fuel CO2 emissions

    46 shares
    Share 18 Tweet 12
  • Sweet discovery could drive down inflammation, cancers and viruses

    43 shares
    Share 17 Tweet 11
  • Wearable mask allows vegetative patients to communicate by breathing

    38 shares
    Share 15 Tweet 10

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Tags

Weather/StormsVehiclesUrbanizationZoology/Veterinary ScienceVaccineWeaponryViolence/CriminalsVirologyVaccinesUrogenital SystemUniversity of WashingtonVirus

Recent Posts

  • Virtual biopsy set to transform heart transplant care
  • Fastest carbon dioxide catcher heralds new age for direct air capture
  • Joint research revealed the importance of anthropogenic vapors on haze pollution over Hong Kong and Mainland China’s megacities
  • Seeing how odor is processed in the brain
  • Contact Us

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

© 2019 Bioengineer.org - Biotechnology news by Science Magazine - Scienmag.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
Posting....