• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • CONTACT US
Thursday, September 21, 2023
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • CONTACT US
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • CONTACT US
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Cancer

Oncotarget: Urine RNA reveal tumor markers for human bladder cancer

Bioengineer by Bioengineer
July 9, 2021
in Cancer
Reading Time: 4 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

This Oncotarget work strongly suggests exploiting urine RNAs as diagnostic markers of bladder cancer and it suggests specific novel markers

IMAGE

Credit: Correspondence to – Georg Sczakiel – [email protected]

Oncotarget published “Transcriptome analyses of urine RNA reveal tumor markers for human bladder cancer: validated amplicons for RT-qPCR-based detection” which reported that in case of bladder cancer, urine RNA represents an early potentially useful diagnostic marker.

Here the authors describe a systematic deep transcriptome analysis of representative pools of urine RNA collected from healthy donors versus bladder cancer patients according to established SOPs.

This analysis revealed RNA marker candidates reflecting coding sequences, non-coding sequences, and circular RNAs.

Next, they designed and validated PCR amplicons for a set of novel marker candidates and tested them in human bladder cancer cell lines.

This Oncotarget work strongly suggests exploiting urine RNAs as diagnostic markers of bladder cancer and it suggests specific novel markers.

This Oncotarget work strongly suggests exploiting urine RNAs as diagnostic markers of bladder cancer and it suggests specific novel markers.

Dr. Georg Sczakiel from The Universität zu Lübeck and UKSH, said “Human bladder cancer (BCa) is one of the most common cancer types in humans.“

With regard to BCa, RNA markers have been studied by transcriptome analyses of single cells, tissue samples and urine.

In case of BCa, urine is thought to be the most promising source for RNA-based tumor markers as direct physical contact between tumor cells and urine seems to be given.

On the other hand, urine RNA samples contain RNAs which are suitable for cDNA synthesis and RT-qPCR detection.

Cell-free RNA contained in urine samples can be protected against degradation, i.e., stabilization of RNA markers is possible such that shipping of samples and storage is possible.

This consists of SOP-based acquisition of urine, stabilization of urine RNA, delivery and storage of samples, RNA preparation, and deep transcriptome analyses.

The Sczakiel Research Team concluded in their Oncotarget Research Output that while all of these hits focus on conventional linear transcripts the authors also noted experimental evidence supporting the existence of circular RNAs that seem to be able to monitor differences between the healthy state and the cancer state.

This is reflected by a number of recent studies describing a link between circular RNA and cancer.

However, such evidence derived from in silico analyses does not necessarily prove that such circRNAs exist in reality.

A set of experimental evidence is necessary to sufficiently strongly verify their existence.

However, such assays go beyond the scope of this study although this is one promising way to proceed in order to identify new and potent RNA markers.

###

DOI – https://doi.org/10.18632/oncotarget.27954

Full text – https://www.oncotarget.com/article/27954/text/

Correspondence to – Georg Sczakiel – [email protected]

Keywords –
tumor diagnostics,
non-invasive,
urine RNA,
biomarker,
transcriptome analysis

About Oncotarget

Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology.

To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with:

SoundCloud – https://soundcloud.com/oncotarget
Facebook – Oncotarget/”>https://www.facebook.com/Oncotarget/
Twitter – https://twitter.com/oncotarget
LinkedIn – https://www.linkedin.com/company/oncotarget
Pinterest – https://www.pinterest.com/oncotarget/
Reddit – Oncotarget/”>https://www.reddit.com/user/Oncotarget/

Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnls

Media Contact

[email protected]
18009220957×105

Copyright © 2021 Impact Journals, LLC
Impact Journals is a registered trademark of Impact Journals, LLC

Media Contact
Ryan James Jessup
[email protected]

Original Source

https://www.oncotarget.com/news/pr/urine-rna-reveal-tumor-markers-for-human-bladder-cancer/

Related Journal Article

http://dx.doi.org/10.18632/oncotarget.27954

Tags: BiologyBusiness/EconomicscancerCarcinogensEducationMedicine/HealthPolicy/Ethics
Share12Tweet8Share2ShareShareShare2

Related Posts

Glen Barber, PhD

Sylvester researcher earns prestigious Columbia University award

September 21, 2023
62-year-old with serum PSA level of 4.11 ng/mL. Prostate MRI shows lesion in left mid anterior transition zone.

Prostate cancer upgrade, downgrade rates in PI-RADS 2.0 versus 2.1

September 21, 2023

Lower risk of haematological cancer after bariatric surgery

September 21, 2023

St. Jude refines definition and hones treatment of hyperdiploid leukemia

September 20, 2023
Please login to join discussion

POPULAR NEWS

  • blank

    Microbe Computers

    58 shares
    Share 23 Tweet 15
  • University of South Florida scientist: Barnacles may help reveal location of lost Malaysia Airlines flight MH370

    46 shares
    Share 18 Tweet 12
  • Lithuanian invention at the forefront of solar technology breakthrough

    41 shares
    Share 16 Tweet 10
  • A pioneering study from Politecnico di Milano sheds light on one of the still poorly understood aspects of cancer

    34 shares
    Share 14 Tweet 9

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

SBQuantum to test quantum magnetometer in space – designed to map Earth’s magnetic field

UW team’s shape-changing smart speaker lets users mute different areas of a room

New study finds that sewage release is worse for rivers than agriculture

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 57 other subscribers
  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In