• HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
Friday, August 29, 2025
BIOENGINEER.ORG
No Result
View All Result
  • Login
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
  • HOME
  • NEWS
  • EXPLORE
    • CAREER
      • Companies
      • Jobs
        • Lecturer
        • PhD Studentship
        • Postdoc
        • Research Assistant
    • EVENTS
    • iGEM
      • News
      • Team
    • PHOTOS
    • VIDEO
    • WIKI
  • BLOG
  • COMMUNITY
    • FACEBOOK
    • INSTAGRAM
    • TWITTER
No Result
View All Result
Bioengineer.org
No Result
View All Result
Home NEWS Science News Cancer

Computational advances in the label-free quantification of cancer proteomics data

Bioengineer by Bioengineer
December 27, 2018
in Cancer
Reading Time: 2 mins read
0
Share on FacebookShare on TwitterShare on LinkedinShare on RedditShare on Telegram

This article by Dr. Feng Zhu et al. is published in Current Pharmaceutical Design, 2018

In recent years, proteomics research has become a popular method for characterizing the functional proteins driving the transformation of malignancy, tracing the large-scale protein alterations induced by anti-cancer drug, as well as discovering the innovative targets and first-in-class drugs for oncologic disorders. Proteomics became popular due to its ability to provide quantitative and dynamic information on tumor genesis and development by directly profiling protein expression. Label-free Quantification (LFQ) is an important method for quantifying protein expression in cancer proteomics. However, the main challenge in using this method for discovering anti-cancer targets and drugs is the low precision, poor reproducibility, and inaccuracy of the LFQ of proteomics data.

This paper presents a review of the recent advances and the computational development of LFQ in cancer proteomics. PubMed and Web of Science databases were searched for label-free quantification approaches, cancer proteomics, and computational advances. A number of experiments including popular acquisition techniques and state-of-the-art quantification tools are critically analyzed and discussed. Following this, the processing approaches which included transformation, normalization, filtering, and imputation were discussed and their impacts on improving LFQ performance of cancer proteomics were evaluated.

The authors also discuss the future direction for enhancing the computation-based quantification technique for cancer proteomics. The dramatic increase in the use of LFQ approaches in cancer proteomics can lead to the enhancement of quantification strategies for studying cancer proteomics in the future once its limitations are accounted for.

###

The article is Open Access till 31st December, 2018. To obtain the article, please visit: http://www.eurekaselect.com/166976

Media Contact
Faizan ul Haq
[email protected]
http://dx.doi.org/10.2174/1381612824666181102125638

Tags: BiochemistrycancerMedicine/HealthMolecular BiologyPharmaceutical ChemistryPharmaceutical SciencePharmaceutical SciencesPharmaceutical/Combinatorial ChemistryToxicology
Share12Tweet8Share2ShareShareShare2

Related Posts

miRNA Resistance in Prostate Cancer: Therapy and Metastasis

August 29, 2025

Reduced 6-Minute Walk Boosts Post-Surgery Readmission Risk

August 29, 2025

Unlocking Cancer of Unknown Primary: Promising Biomarkers Identified

August 29, 2025

Mesenchymal Stem Cells: Beneficial or Harmful in AML?

August 28, 2025
Please login to join discussion

POPULAR NEWS

  • blank

    Breakthrough in Computer Hardware Advances Solves Complex Optimization Challenges

    150 shares
    Share 60 Tweet 38
  • Molecules in Focus: Capturing the Timeless Dance of Particles

    142 shares
    Share 57 Tweet 36
  • New Drug Formulation Transforms Intravenous Treatments into Rapid Injections

    116 shares
    Share 46 Tweet 29
  • Neuropsychiatric Risks Linked to COVID-19 Revealed

    82 shares
    Share 33 Tweet 21

About

We bring you the latest biotechnology news from best research centers and universities around the world. Check our website.

Follow us

Recent News

Metabolomics Reveals Meat Quality in Dolang Sheep

Cocoa Research in Africa: Insights on Production and Trade

Exploring Antibacterial Arylhydrazones: Structure-Activity Insights

  • Contact Us

Bioengineer.org © Copyright 2023 All Rights Reserved.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • Homepages
    • Home Page 1
    • Home Page 2
  • News
  • National
  • Business
  • Health
  • Lifestyle
  • Science

Bioengineer.org © Copyright 2023 All Rights Reserved.