Cancer
Precision Brachytherapy Improves Dosimetry in Salvage Treatment for Recurrent Gynecologic Cancers
A retrospective study analyzed 27 patients treated with transvaginal HDR-ISBT for centrally recurrent pelvic gynecologic malignancies, finding that 3D-PT-assisted implantation...
RNA Modifications and Metabolism: Decoding Crosstalk in Liver Cancer
RNA modification networks and metabolic reprogramming establish reciprocal circuits that drive hepatocellular carcinoma progression and therapeutic resistance.
Artemisinin May Curb Gastric Cancer Cells by Damping ERK Signaling
A new in vitro study reports that artemisinin suppresses gastric cancer cell proliferation, migration, and invasion while reducing ERK/MAPK pathway...
Rare MSH2 Variant Linked to Three Cancers in One Lynch Syndrome Patient
A Frontiers in Oncology case report documents a 62-year-old woman carrying the known pathogenic MSH2 p.A230Lfs*16 germline variant who developed...
THOR hypermethylation drives hTERT reactivation in cervical cancer
A study of Indian cervical cancer patients links THOR hypermethylation to hTERT reactivation and reduced menin recruitment, independent of HPV...
Palliative Sedation Often Follows a Cascade of Refractory Symptoms, Not a Single One
An international observational study of 80 advanced cancer patients finds that palliative sedation is typically prompted by multiple interacting refractory...
Pembrolizumab Brings Heavy Toxicity Burden for Older Breast Cancer Patients in Real-World Care
A real-world cohort study of 136 patients aged 65 and older found high rates of hospitalization and immune-related toxicity with...
STAM protein suppresses kidney cancer through a dual EGFR and AKT mechanism
New preclinical research shows the STAM protein suppresses clear cell renal cell carcinoma by inactivating EGFR and degrading AKT, inducing...
TIGIT receptor drives NKT-like cell exhaustion in high-HBV liver cancer patients
A study finds that the inhibitory receptor TIGIT impairs NKT-like cell function in hepatocellular carcinoma patients with high hepatitis B...
Rising Cancer Stemness Drives Prostate Cancer Progression and Treatment Resistance
A large integrated transcriptomic study shows that rising cancer stemness tracks prostate cancer progression, lineage plasticity, therapy resistance, and poor...
Ultrasound patterns may help tell IgG4-positive Hashimoto’s thyroiditis apart from thyroid lymphoma
A pilot study found that marked thyroid enlargement, very hypoechoic echogenicity, and posterior acoustic enhancement on ultrasound were far more...
Diabetes Drugs Linked to Sharply Lower Lymphedema Risk After Breast Cancer Surgery
A large real-world cohort study finds that breast cancer patients exposed to GLP-1 receptor agonists had a much lower incidence...
PD-L1 Levels Fail to Predict ALK Inhibitor Benefit in Lung Cancer Cohort
A 129-patient Japanese multicenter study found that tumor PD-L1 expression did not predict the effectiveness of ALK inhibitor therapy in...
Before Treatment Begins, Lung and Head and Neck Cancer Patients Know Little About Exercise
A qualitative study of 14 Brazilian patients found that before starting treatment for lung or head and neck cancer, most...
Machine Learning Study Links ENTPD5 to Radioresistance in Liver Cancer
An integrated machine-learning and single-cell study identifies ENTPD5 as a context-dependent candidate marker of radioresistance in hepatocellular carcinoma, with prognostic...
PET scans predict survival in peripheral T-cell lymphoma, meta-analysis finds
A meta-analysis of nine studies in 851 patients links higher Deauville scores on interim and end-of-treatment PET/CT scans to worse...
Body Image Distress Rises in Final Months for Pancreatic Cancer Patients of Both Sexes
Post-hoc analyses of the Swedish MISTRAL trial show that body image distress and weight worries increased significantly in both women...
Gemcitabine-Fused microRNA Shows Promise Against Chemoresistant Colorectal Cancer in Preclinical Models
A gemcitabine-modified tumor-suppressor microRNA called Gem-miR-15a overcame 5-FU and oxaliplatin resistance in preclinical colorectal cancer models with low-nanomolar potency and...
Caregivers of Older Blood Cancer Patients Carry Heavier Cognitive Burden Than Patients
A cross-sectional survey of 428 patient-caregiver dyads found that primary caregivers of older adults with hematologic malignancies reported significantly higher...
Fibroblasts May Help Endometrial Tumors Evade Immunity, but the Evidence Is Still Patchy
A new review finds that while cancer-associated fibroblasts clearly promote tumor growth and suppress natural killer cell activity in endometrial...
POPULAR NEWS
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Diffusion AI generates synthetic dysarthric speech to sharpen intelligibility classifiers
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Prompt-engineered embeddings fail to beat strong tabular models in demand forecasting benchmark
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Photon-counting CT sharpens lung nodule images at lower radiation doses, review finds
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Psychiatric Service Dogs Ease Loneliness in South African Adults With Mental Illness