Cancer

Preclinical hepatocellular carcinoma models showed that blocking ACSS2 or autophagy enhanced cabozantinib’s antitumor activity by disrupting a TFEB-linked protective response.

In a mouse osteoarthritis model, moderate treadmill exercise altered the gut microbiota, lowered circulating lactate and reduced cartilage damage through...

A systematic review finds that gut microbes and metabolites may shape the liver immune environment associated with immunotherapy response in...

A small clinical study linked lipid metabolism and mitochondrial respiration to low CD8-positive T-cell infiltration in esophageal adenocarcinoma using spatial...

Global Burden of Disease estimates show that Mexico’s age-standardized prostate cancer burden declined from 2000 to 2023, while more marginalized...

A small single-arm trial found preliminary platelet-recovery activity and no serious adverse events among 37 Chinese patients with gynecologic malignancies...

A meta-analysis of four observational studies involving 110 patients associated cardiac resynchronization therapy with improved ejection fraction and reduced left-ventricular...

A six-center retrospective study of 275 osimertinib-treated patients associated postoperative recurrence with longer progression-free and overall survival than de novo...

A National Cancer Institute-funded phase 2/3 trial will test ivonescimab plus chemotherapy against standard chemoimmunotherapy in U.S. patients with advanced...

A small regional pilot trial found supervised aerobic exercise before cancer surgery was well attended and caused no serious adverse...

A transparent 3D Cell Painting method revealed that two cancer drugs with similar effects in flat cultures diverged inside minispheres...

A narrative review finds that artificial intelligence can support Gamma Knife planning, outcome prediction and toxicity assessment, but predominantly retrospective...

A systematic review of 67 studies involving 2,558 children found that shear-wave elastography shows promise for assessing and monitoring musculoskeletal...

Single-cell and bulk transcriptomic analyses linked TIMP1 to anoikis resistance in esophageal squamous cell carcinoma, while cell and mouse experiments...

Cell experiments found that silencing GFPT1 reduced proliferation, migration and invasion in esophageal cancer cells, with a rescue experiment supporting...

In a prospective study of 33,568 men followed for a median of 15.9 years, at least nine hours of weekend...

A meta-analysis of 11 non-European cohort studies associated each 10 ppb increase in nitrogen dioxide with an 8% higher lung...

A 2026 review finds that several non-coding RNAs are associated with tumor-associated macrophage states, pathways linked to colorectal cancer progression,...

A narrative review of 53 studies finds that artificial intelligence can extract and analyze brain-tumor symptom data, but limited validation...

An exploratory study of 30 pancreatic cancer patients and 30 healthy controls found similar diagnostic performance for 1,4-dimethylpiperazine and CA19-9,...