Biology
Iron Overload, Ferroptosis and the Liver: Mapping a Deadly Network
A new review maps how disrupted iron homeostasis and ferroptosis drive liver disease, from hereditary hemochromatosis to hepatocellular carcinoma, and...
Plant trait turnover and microbe networks drive forest multifunctionality across landscapes
A study of 24 subtropical forest plots in Yunnan, China, finds that plant functional trait turnover and plant–microbe network turnover,...
Vegetarian diet does not offset ABCG2 gene variant’s hyperuricemia risk in Taiwanese cohort
A Taiwanese study of over 11,000 people found the ABCG2 rs2231142 variant raises hyperuricemia risk similarly in vegetarians and non-vegetarians.
Short-Term CD8+ T Cell Depletion Alters Tau Pathology in Aged Alzheimer’s Model Mice
Brief antibody-mediated depletion of CD8+ T cells in aged APP/PS1 mice left amyloid plaques unchanged but reduced dystrophic neurites and...
Popular endurance models fail to predict runners’ interval performance, study finds
A new study of trained runners shows that all four established W′-balance models, developed for cycling, dramatically overpredict how many...
Animal markets linked to higher viral diversity and virus–host connectivity
A metatranscriptomic study in Guangdong, China, found that animal-market samples showed higher viral richness, distinct virome structure and broader virus–host...
Optimized root-pulling force protocol speeds wheat root screening in sandy field
An optimized root-pulling force protocol enables rapid field screening of mature wheat cybrids, measuring over 1000 plants in 24 working...
Dumpsites emerge as hotspots for mosquito arbovirus vectors in Thailand
A survey of seven human-animal interfaces in two Thai border provinces found dumpsites harboured the highest burdens of mosquito arboviral...
New Barcoded Yeast Library Maps Gene-Drug Interactions Across 262 Strains
A new CRISPR-Cas9 barcoded library, BarMix, profiles 262 diverse yeast strains against 33 compounds and reveals 281 chemogenomic interactions.
New Marine Amoeba Yields One of the Best Rhizarian Genomes Yet
A chromosome-level genome assembly of the newly named marine amoeba Lemnamoeba sinaloensis reveals a compact 27 Mb genome rich in...
Mutations in hepatitis E virus ORF1 shape replication and disease severity
A new review synthesises evidence that specific mutations in the hepatitis E virus ORF1 polyprotein alter viral replication and are...
Seasonal Shifts and Site Conditions Drive Red Sea Benthic Biodiversity Patterns
A four-season survey at three Egyptian Red Sea sites recorded 2,942 benthic individuals from 60 species and found that season...
Yeasts Lead the Race to Mass-Produce Next-Generation Antimicrobial Peptides
A new review argues that yeasts, especially Pichia pastoris, are the leading fungal platforms for scalable recombinant production of antimicrobial...
Stem Cell-Derived Schwann Cells Emerge as a Human Model for Peripheral Neuropathy
A new review examines how Schwann cells grown from human pluripotent stem cells are being used to model peripheral neuropathies...
Circular RNA Shows Protective Signals in Mouse and Cell Models of Sepsis-Linked Kidney Injury
A new study reports that circ_0000745 attenuated renal and cellular injury endpoints in mouse and cell models of sepsis-induced acute...
Yeast Evolves Resistance to Coal-Washing Chemical by Losing a Key Transcription Factor
Laboratory-evolved yeast strains gained resistance to the synthetic hydrotrope MCHM through recurring loss-of-function mutations in the transcription factor gene PDR3,...
Muscle repair gene CSRP3 works in pigs but not mice, study finds
A new study shows the CSRP3 gene is essential for satellite cell differentiation and muscle regeneration in pigs but dispensable...
Metal-Resistant Fungi Offer New Routes to Shield Plants from Heavy Metal Stress
A review in Plant Cell Reports examines how metal-resistant fungi mitigate heavy metal stress in plants through biosorption, bioaccumulation and...
Mycorrhizal fungus helps three Sphagneticola plants cope with cadmium stress
Inoculation with the arbuscular mycorrhizal fungus Funneliformis mosseae raised acid phosphatase activity and phosphorus uptake in three Sphagneticola species grown...
Nanoscale map charts the spatial organization of the human cell surface
Proximity labeling of 85 antigens on human immune cells has produced a nanoscale map of the surface proteome, revealing functional...
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