Biology
Gene mutation dosage predicts prognosis and metastasis across 60,000 cancer samples
In one of the largest analyses of tumor genetics ever assembled, an international team of researchers has shown that the...
Galectin-1-high monocytes boost functional memory CD8+ T cell generation
When a virus invades the lungs, the immune system mounts a noisy, visible battle: fever, inflammation, floods of white blood...
Engineering a kinase-controlled allosteric switch for improved performance
Scientists have unveiled a powerful new strategy for building protein switches that can be turned on and off by cell...
ATRX partners with 9-1-1 and CST to protect genome replication and telomeres
Every time a human cell divides, it must copy roughly six billion letters of DNA—a feat accomplished by molecular machines...
Metformin restores mitochondrial quality control in Down syndrome fibroblasts
Mitochondrial dysfunction has long been recognized as a central feature of Down syndrome, but the precise reasons why the cell’s...
Multiomics approach reverses age-related disease susceptibility in oysters
In the world of infectious disease, aging is almost universally a liability. As animals grow older, their immune systems typically...
New R package Geneslator simplifies gene ID conversion and annotation
Every high-throughput sequencing experiment ends in the same place: a very long list of genes, each tagged with an identifier...
Fragmented gut and airway microbes mark preschool wheeze, driven by Moraxella clustering
Recurrent wheezing in preschool children is one of the most common reasons young children visit respiratory clinics, and it is...
Microcapsules deliver probiotic-derived extracellular vesicles via mucosal adhesion
Researchers in Argentina have engineered microscopic capsules that not only shield probiotic bacteria from the harsh chemistry of the stomach...
Losing desmoplakin in lung epithelium triggers fibrotic Wnt signaling in vitro
Idiopathic pulmonary fibrosis has long been framed as a disease of runaway wound healing, in which the delicate air sacs...
Genetic diversity of full-length HLA-E gene characterized in Estonians
In a small Baltic nation better known for its medieval old towns and digital governance than for immunogenetics, a team...
Narcissus transcriptomics reveals modified ABCDE model and double flower mechanism
For centuries, gardeners have prized double flowers—blooms in which stamens quietly surrender their pollen-bearing duties and transform into extra layers...
Cyclin gene evolution in Arabidopsis and Brassica links polyploid duplication to flowering time
In a finding that could reshape how breeders approach one of the world’s most important oilseed crops, researchers at The...
Genetic Structure and Environment-Linked Loci in a Resilient Coral Along Eutrophication Gradient
In the murky, nitrogen-rich waters of Hong Kong, one coral species seems to thrive where others perish, and a new...
Genome Analysis Identifies Multi-Epitope Vaccine Targets Against Drug-Resistant Enterobacter
A multidrug-resistant bacterium that has quietly become one of the most feared residents of modern hospitals may soon face an...
Loneliness drives depression and poor health among older European adults, study finds
Loneliness may be one of the most powerful and overlooked forces shaping the health of older Europeans, and its effects...
Two Ways to Read a Cell’s Master Switches Reveal Hidden Biases in Gene Regulation Studies
Transcription factors are the master regulators of the genome, the proteins that decide which genes are switched on, which are...
BRWD3 Mutation Identified in Female with X-Linked Intellectual Disability
A rare genetic disorder long considered a disease of boys has now been documented in a young girl carrying a...
Using 12-lead ECG to locate premature heartbeats in horses
Cardiac arrhythmias are common in horses, but for decades equine veterinarians have faced a frustrating diagnostic blind spot: when an...
Integrated bioinformatics profiling of the lysine demethylase gene family in breast cancer
{“title”:”Epigenetic Enzymes Emerge as Powerful New Predictors of Breast Cancer Patient Survival and Treatment Response”,”html”:”Breast cancer remains one of the...