Tag: tumor-associated macrophages

Researchers identified a DDX3X-METTL3 molecular axis that promotes glioma progression by altering the tumor immune microenvironment and macrophage infiltration.

Researchers have revealed that the glycolytic enzyme PFKFB4 accelerates hepatocellular carcinoma growth by stimulating lactate-driven histone lactylation to polarize tumor-associated ...

A new review proposes that persistent pathogens remodel the tumor immune microenvironment, promoting immune escape and immunotherapy resistance through checkpoints, ...

Engineered exosome-liposome hybrid nanoparticles targeting CSF1R and PD-L1 stimulate macrophage phagocytosis across several brain cancer cell models in vitro, though ...

Spatial profiling of melanoma tumors reveals that lipid-associated macrophage neighborhoods drive immune exclusion and predict resistance to checkpoint inhibitor therapy.

A new study reveals that SPP1-positive tumor-associated macrophages promote cervical cancer progression by activating the NF-κB pathway in tumor cells ...

Researchers uncover how fine particulate matter and tobacco carcinogens cooperate with glucose to accelerate colorectal cancer growth through macrophage-driven immune ...

A new Frontiers editorial argues that mechanical forces in tumors regulate invasion, immune surveillance, and treatment response, and that the ...

A new narrative review in Frontiers in Oncology details how T cells, macrophages, neutrophils, B cells, NK cells, and dendritic ...

A computational study identified KRT14 and MMP10 as macrophage-associated candidate biomarkers of chemoradiotherapy response in esophageal squamous cell carcinoma.

A preclinical study reports that ginseng-derived ginsenoside Rg3 binds Glut1 on tumor-associated macrophages, reprograms their metabolism, and enhances anti-PD-1 therapy ...

A new review details how metabolically reprogrammed cancer-associated fibroblasts build immune-excluded and immunosuppressive tumor niches that undermine checkpoint blockade, and ...

A new cell-culture study reports that an EGFR-IL-8 signaling loop between liver cancer cells and macrophages sustains lenvatinib resistance in ...

A preclinical study reports that formononetin from Jianpi Tongluo Formula suppresses colorectal cancer progression by inhibiting M2 tumor-associated macrophage polarization ...

Single-cell and multi-omics analyses of hepatocellular carcinoma point to IL-1β-positive macrophages and IL-1R1-positive inflammatory fibroblasts as putative drivers of a ...

A new narrative review finds that the clinical meaning of immune infiltration in bladder cancer depends on cell localization, functional ...

Researchers have identified a rare CD4-lineage progenitor in adult mouse bone marrow that generates macrophages, neutrophils and erythroid cells independently ...

Single-cell sequencing and mouse experiments show that PTN-positive glioblastoma cells recruit anti-inflammatory macrophages through a PTN-NCL interaction, creating the immune ...

A 2026 review finds that several non-coding RNAs are associated with tumor-associated macrophage states, pathways linked to colorectal cancer progression, ...

A 2026 narrative review finds that most myeloid-directed cancer programs show target activity without proving immune conversion and proposes a ...