AI Deciphers the Hidden Spatial Rules That Guide Immune Cells Through Tissues
An interpretable machine learning framework called SPACER decodes the gene-level rules that recruit or exclude immune cells in tissues, revealing ...
Tag: Spatial transcriptomics
Single-cell atlas reveals how hidden clones drive pancreatic cancer’s deadly evolution
A landmark single-cell and spatial transcriptomics study of 62 pancreatic tumors shows that genetically distinct clones within each cancer drive ...
Shared Genes, Opposing Effects: Hidden Genetic Link Between Heart Failure and Osteoporosis Revealed
A multi-omics study reveals that heart failure and osteoporosis share hundreds of genetic variants that often act in opposite directions, ...
Cell Maps of Endometriosis Reveal Nerve and Immune Hubs That May Drive Pain
A high-resolution spatial transcriptomic atlas of human ovarian and peritoneal endometriosis lesions reveals conserved fibroblast niches and sensory neuroimmune interactions ...
NIH Backs Boston University Team Building Biomarkers to Catch Lung Cancer Earlier
A five-year, $3.4 million National Cancer Institute grant will help a Boston University-led consortium translate the Lung Pre-Cancer Atlas into ...
Hidden Fibroblast State at the Pancreatic Tumor Frontier Predicts Poor Survival and Points to Existing Drugs
Integrating single-cell and spatial transcriptomics, researchers identified a novel invasive-frontier fibroblast state and the multicellular community it defines, which independently ...
Hidden Brain Cells Called Oligodendrocytes Emerge as Unexpected Drivers of Parkinson’s Disease
A spatial multi-omics study in Nature Communications identifies disease-associated oligodendrocytes whose interleukin 33–ST2 signaling influences alpha-synuclein burden and motor symptoms ...
New AI Framework Reads Gene Maps Like Images to Reveal Hidden Cell States
A new computational framework called STARIT converts the spatial positions of mRNA molecules inside cells into image tensors, allowing deep ...
The Fibroblast Problem: Why Liver Cancer Drugs So Often Fail
A new review identifies three fibroblast-driven mechanisms that make liver cancer cells resistant to kinase inhibitors and immunotherapy, while warning ...
Cholesterol’s Hidden Geography: How Tumor Neighborhoods Fuel Resistant Prostate Cancer
A paired spatial multi-omics study of prostate cancer reveals that rising cholesterol during therapy tracks with castration resistance, as import-dominant ...
Landmark heart atlas reveals two-phase collapse of the failing right ventricle
A multi-platform transcriptomic atlas of the human right ventricle reveals a two-phase progression to failure, with early erosion of protective ...
Scientists map the cellular blueprint that sculpts every human face
A new single-cell and spatial atlas of the developing human face identifies 56 cell states, hundreds of spatial patterning genes ...
Macrophage Signal WNT5A Drives Lung Cancer Scarring That Blocks Immunotherapy
A new study reveals how SPP1-positive macrophages secrete WNT5A to activate matrix-remodeling fibroblasts in lung adenocarcinoma, building a stiff tumor ...
New Sequencing Method Captures the Hidden Conversations Between Cells
A new method called CCI-seq captures large-scale cell–cell interaction networks in tissues while preserving full single-cell transcriptomes, revealing interaction-driven gene ...
Hidden Immune Saboteurs: Scientists Map the Cells That Shield Colorectal Tumors
By combining spatial and single-cell transcriptomics, researchers have mapped previously unknown immunosuppressive niches in colorectal cancer, including SPP1-positive macrophage rings ...
First Multiomic Atlas Reveals How the Human Brain’s Protective Layers Build Their Immune Defenses
A paired single-nucleus RNA and chromatin atlas with spatial transcriptomics charts how the human meninges, their blood-brain barrier endothelium, yolk ...
Scientists map the developing human heart cell by cell and reveal how Down syndrome disrupts it
A multimodal atlas of the developing human heart reveals 21 tissue niches, shows fetal pacemaker cells recruiting their own nerve ...
AI Method Reads Tissue Fingerprints to Find Disease Hotspots Earlier
A new deep-learning method called VIMA converts tissue patches into numerical fingerprints and uses rigorous statistics to uncover disease-associated spatial ...
ResolVI cleans up noisy spatial transcriptomics data after segmentation goes wrong
A new probabilistic deep learning model called ResolVI corrects misassigned RNA molecules and batch effects in spatial transcriptomics data, sharpening ...
Human Meninges Cell Atlas Upends Century-Old View of Meningioma Origins
The first single-cell and spatial atlas of the developing human meninges shows that meningioma tumours transcriptionally resemble dura mater cells ...
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