AI Model SPACER Decodes the Hidden Rules of Cell Recruitment in Human Tissue
An interpretable deep learning model called SPACER reads spatial transcriptomics data to reveal the molecular and spatial rules that govern ...
Tag: Spatial transcriptomics
Scientists Pinpoint the Moment Stress Turns Into Depression in the Brain
A new Nature Neuroscience study maps a precisely timed, seven-day window in which chronic stress remodels the mouse lateral habenula ...
Scientists Map the Hidden Cellular Wiring That Drives Rheumatoid Arthritis Joint Destruction
A cross-species single-cell and spatial transcriptomics study reveals a conserved Notch/AP-1 to fibronectin and thrombospondin signaling axis operating in a ...
Ancient somatosensory circuit architectures employ flexible molecular strategies
A study of little skate embryos reveals that the layered spinal cord and target-dependent maturation of touch and pain circuits ...
Fibroblast collagen signal drives gut scarring and cancer in inflammatory bowel disease
A single-nuclei study reveals how CXCL14+ fibroblasts and SPP1+ macrophages form a collagen IV-driven feedback loop that promotes fibrosis and ...
Myeloid IL6/STAT3 Signaling Builds Immunosuppressive Niche That Fuels Colitis-Linked Cancer
Multi-omics study reveals how myeloid-derived IL6/JAK/STAT3 signaling creates a spatially organized immunosuppressive niche that drives colitis-associated carcinogenesis, offering a potential ...
Single-Cell Sequencing Reveals Why Diabetic Foot Ulcers Refuse to Heal
A new review details how single-cell RNA sequencing is exposing the cellular and molecular failures that keep diabetic foot ulcers ...
Enhanced Recovery Care Reshapes Immune Response After Bladder Cancer Surgery
A retrospective study of 126 bladder cancer patients suggests that ERAS-based perioperative nursing care is associated with gentler postoperative immune ...
Scientists Map the Cellular Ecosystem That Drives Liver Cancer Spread Through Blood Vessels
Single-cell RNA sequencing of hepatocellular carcinoma reveals that MRC1-positive macrophages, endothelial capillarization, and strengthened PTPRM signaling define the tumor ecosystem ...
How Persistent HPV Infection Drives Cervical Precancer: Molecular Pathways, Immune Evasion and Emerging Technologies
A new review in Cellular and Molecular Life Sciences maps the molecular pathways, immune microenvironment and AI-driven technologies that shape ...
Spatial Niches May Explain Why Brain Implants Lose Their Signal Over Time
A new analytical framework proposes that spatial niches — recurring local cellular and molecular neighborhoods around implanted microelectrodes — could ...
Spatial Transcriptomics Maps the Cellular Battlefields of Fatal COVID-19 Lungs
A spatial transcriptomics study of fatal COVID-19 lungs reveals progressive loss of endothelial and immune cells, explosive peribronchial fibroblast expansion, ...
One Brain Map, Two Diseases: Alzheimer’s and Multiple Sclerosis Share a Genetic Signature of Shrinkage
A large trans-disease meta-analysis of more than 6,900 brain scans finds that Alzheimer's disease and multiple sclerosis share a common ...
New spatial sequencing method maps RNA turnover kinetics across the mouse brain
Spatial NT-seq combines metabolic RNA labeling with in situ chemical recoding to co-map newly synthesized and pre-existing RNAs, revealing the ...
How the Four-Eyed Fish Rebuilt Its Retina to See in Air and Water at Once
Researchers have shown that the four-eyed fish Anableps anableps evolved its aerial vision through developmental expansion of the ventral retina ...
Intranasal Herpes Virus Remodels Brain Immune Cells in a Region-Specific Pattern
A multiomic study in PLOS Pathogens shows that intranasal HSV-1 infection drives localized, interferon-dominated remodeling of microglia in discrete brainstem ...
Hidden Cell-to-Cell Messaging Networks Drive Triple-Negative Breast Cancer Resistance
A new review argues that triple-negative breast cancer's heterogeneity and therapy resistance emerge from spatially organized paracrine signaling networks between ...
New Algorithm Zooms Across Scales to Reveal Hidden Signals in Spatial Genomics
Researchers have developed SpatialZoomer, a spectral graph-based tool that automatically identifies the biologically meaningful scales in spatial transcriptomics data, revealing ...
New AI Model Decodes the Signals That Guide Immune Cells Into Tumors
Researchers at MD Anderson developed an AI tool called SPACER that decodes the spatial signals attracting or repelling immune cells ...
Lost Tumour Suppressor on Chromosome 6q Drives Deadly Childhood Brain Cancer and Reveals a Drug Target
New research shows that loss of the tumour suppressor LATS1 on chromosome 6q drives Hippo pathway dysregulation in ultra-high-risk PFA ...
POPULAR NEWS
-
Study Examines Artificial Intelligence Prospects for Food Security Across Nigeria and South Africa
-
Caregiver Burden Tracks With Anxiety in Parents of Children With SMA Type 1
-
Ultrasound Drainage and Oscillatory Ventilation Resolve Severe Neonatal Lung Infection
-
Study Details Shifting Dynamics of Other Infectious Diarrhea in Kunming