Antiemetic Drug Combination Linked to Elevated Diabetes Risk in Chemotherapy Patients
A large Japanese health claims analysis found that combining neurokinin-1 receptor antagonists with dexamethasone significantly increased the odds of new-onset ...
Tag: solid tumors
Engineered Materials Offer New Framework for Controllable Cellular Immunotherapy
A review in Discover Oncology examines how engineered materials can address manufacturing, delivery, and safety bottlenecks across cellular immunotherapy.
Engineered CAR Dendritic Cells Suppress Tumor Growth in Mouse Models
Researchers engineered chimeric antigen receptor dendritic cells incorporating CLEC9A or DEC205 domains, suppressing tumor growth in mouse models.
Triple-Marker T Cell Profiling Pinpoints Tumor-Specific Receptors in Colorectal Cancer
Scientists have demonstrated a triple-marker screening strategy to isolate tumor-specific T-cell receptors from colorectal cancer lymphocytes.
Mitochondrial Adaptability Governs CAR-T Cell Persistence and Efficacy in Cancer Immunotherapy
A comprehensive review outlines how engineering mitochondrial adaptability can overcome metabolic exhaustion and enhance CAR-T cell persistence in cancer therapy.
Cell and Gene Therapy Advances Face Manufacturing and Long-Term Safety Hurdles
A meeting report from the 5th China Annual Congress on Cell and Gene Therapy highlights clinical progress in immune and ...
Computational Study Identifies Promising Novel siRNA Candidate Targeting Tumor Glucose Transporter GLUT-3
Researchers have used multi-stage computational modeling and molecular dynamics simulations to design and screen novel small interfering RNAs targeting the ...
Aggressive Tumor Cell Models Retain Broad Drug Sensitivity in Laboratory Testing
An analysis of mesenchymal-like solid tumor cell lines reveals they retain broad drug vulnerabilities in vitro, suggesting microenvironmental barriers drive ...
GLP-1 Receptor Agonists Tied to Better Survival in Cancer Immunotherapy Cohorts
A meta-analysis of six retrospective cohort studies found that GLP-1 receptor agonist use was associated with improved overall survival in ...
ICU Atrial Fibrillation Mortality Risk Spikes in Cancer Patients With Thrombocytopenia
A retrospective study of over 9,600 critically ill cancer patients reveals that new-onset atrial fibrillation surrogates are linked to elevated ...
Review Outlines MUC1-Directed CAR T Cell Strategies Against Solid Tumors
A scientific review evaluates advances in MUC1-directed CAR T cell design and combinatorial strategies to tackle solid tumor barriers.
Basket Trial Evaluates Oral Ponatinib for Solid Tumors With Genomic Alterations
A phase 2 basket trial found oral ponatinib did not meet its primary endpoint in solid tumors with FGFR alterations, ...
Peptide-Functionalized Biomaterials Could Boost CAR-NK Cell Therapy Against Solid Tumors
A new review examines how peptide-functionalized hydrogels and scaffolds could support CAR-NK cell therapy in solid tumors, while noting that ...
Antibody-Drug Conjugates Face Clinical Resistance and Toxicity Challenges in Solid Tumors
A review in Molecular Cancer examines how antibody-drug conjugates treat solid tumors while addressing clinical resistance, toxicity profiles, and narrow ...
Intraperitoneal Infusion Improves CAR-T Cell Therapy in Solid Tumor Models
In solid tumor models, intraperitoneal infusion improved CAR-T cell antitumor efficacy and persistence compared to standard intravenous delivery.
Study Analyzes Pediatric Major Illness Patterns and Healthcare Disparities Across China
A spatial analysis of 13,112 platform-reported pediatric major-disease cases in mainland China reveals pronounced regional clustering, healthcare resource inequalities, and ...
MASCC and CISNE Show Similar Mortality Prediction in Stable Febrile Neutropenia
A prospective emergency department cohort study found that MASCC and CISNE scores had comparable discrimination for 30- and 90-day mortality ...
Review Synthesizes Musashi-2 Mechanisms in Post-Transcriptional Disease Regulation
A scientific review highlights Musashi-2 as a context-dependent post-transcriptional organizer involved in stabilizing pathological cellular states across diverse diseases.
Targeted Tumor Irradiation Controls Localized CAR-T Cell Release of TNF
Engineered CAR-T cells equipped with a synthetic radiation-inducible promoter locally release tumor necrosis factor upon tumor irradiation to enhance antitumor ...
Review Identifies ATG5 as Context-Dependent Switch in Cancer Drug Resistance
A scientific review published in Cancer Cell International highlights ATG5 as a context-dependent molecular switch driving therapy resistance and survival ...
POPULAR NEWS
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