Cancer cells flood tumors with palmitate that exhausts CAR-T cells
Researchers report that the epigenetic regulator BAZ2A drives renal cancer cells to accumulate palmitic acid, which impairs CAR-T cell mitochondria ...
Tag: solid tumors
Engineered IL-6-Responsive CAR Macrophages Boost CAR-T Cell Activity Against Solid Tumors
Engineered IL-6-responsive CAR macrophages enhanced CAR-T cell antitumor activity, matrix remodeling, and survival in preclinical solid tumor models.
CAR-NK Cells Move From Concept Toward Clinic as Review Maps Engineering Fixes
A new review synthesizes engineering strategies and early clinical findings for CAR-NK cell immunotherapy in blood cancers and solid tumors.
Ascites metabolism differs sharply depending on tumor cells
A prospective metabolomic study of 35 patients with solid tumors found that ascites fluid shows distinct metabolic profiles depending on ...
Cancer genome profiling uncovers hidden inherited cancer risk in one in ten patients
A prospective trial found constitutional pathogenic variants in about 10 percent of solid tumor patients screened through comprehensive cancer genome ...
Preclinical thyroid cancer study restores CAR-T target with targeted drugs
A preclinical Mayo Clinic study found that MAPK inhibitors restored TSHR on anaplastic thyroid cancer cells and improved tumor control ...
Preclinical plug-and-play CAR T cells can be reconfigured after treatment
An animal study by City of Hope researchers shows that modular CAR T cells can accept engineered adaptors after treatment, ...
Adaptive sampling brings rapid whole-genome profiling to pediatric cancer diagnosis
Canadian researchers report that a single Oxford Nanopore whole-genome sequencing assay with adaptive sampling detected fusion genes, small variants, copy ...
313TE targets IL-13Rα2-positive tumors in preclinical testing
A preclinical study reports that the IL-13E13Y-based T-cell engager 313TE linked IL-13Rα2-positive tumor cells to T cells, promoting receptor-dependent killing ...
First DS1025 dose administered in international Phase 1 solid-tumor trial
Kansai Medical University Hospital gave the first worldwide dose of investigational CD25-directed antibody drug conjugate DS1025 in a global Phase ...
MSIPep prioritizes tumor peptides in leukemia and solid-tumor datasets
MSIPep combines immunopeptidomics, transcriptomics and deep learning to identify and computationally prioritize candidate tumor peptides in leukemia and solid-tumor datasets.
Myeloid drugs rarely prove immune conversion in solid tumors
A 2026 narrative review finds that most myeloid-directed cancer programs show target activity without proving immune conversion and proposes a ...
Big Data Cancer Biomarker Studies Advance Discovery but Await Clinical Validation
Eleven studies using machine learning, single-cell profiling, imaging, liquid biopsy and clinical data identify candidate cancer biomarkers, but retrospective designs ...
Autophagy’s Context-Dependent Roles Shape Solid-Tumor Treatment Strategies
A 2026 collection of five reviews and one small tissue-expression study shows that autophagy can restrain or support solid tumors ...
Single-Cell Sequencing Extends Tumor Analysis to Fixed Clinical Samples
A Roche-led benchmark found that the 10X Genomics GEM-X Flex assay with chop-fix processing improves single-cell RNA profiling of frozen ...
Antibody–Drug Conjugates Reshape Solid Tumor Therapy Amid Safety and Target Challenges
A new review in Holistic Integrative Oncology charts the rapid rise of antibody–drug conjugates in solid tumors while detailing the ...
Gene brake ZMYND8 drives T-cell exhaustion and blocking it may strengthen immunotherapy
St. Jude scientists found that deleting the gene ZMYND8 relieves CD8-positive T-cell exhaustion and synergizes with immunotherapy to improve anti-tumor ...
HIV-Linked Blood Cancers Strike Younger Patients and Cut Survival, Single-Center Study Finds
A retrospective cohort study of 166 people living with HIV finds that hematologic malignancies strike younger patients, track with high ...
UChicago Medicine Trials Homegrown Engineered T-Cell Therapy for Advanced Solid Tumors
UChicago Medicine has launched a first-of-its-kind investigator-initiated clinical trial of a fully on-site manufactured T-cell receptor therapy engineered to target ...
Three-Day Whole Genome Sequencing Transforms Childhood Cancer Diagnosis
A UK study shows rapid whole genome sequencing cuts pediatric cancer diagnosis time from six weeks to three days while ...
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